Featured
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Review Article |
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
In this Review, Bäckhed and colleagues summarize the evidence for gut microbiome alterations in cardiometabolic and cardiovascular diseases and the rationale and potential benefit motivating translational approaches to target the gut microbiota and its metabolites for prevention and treatment.
- Rima Mohsen Chakaroun
- , Lisa M. Olsson
- & Fredrik Bäckhed
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Review Article |
Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease
In this Review, the authors describe the mechanisms underlying lipopolysaccharide translocation from the gut to the systemic circulation and the ensuing low-grade endotoxaemia, discuss studies suggesting a role for low-grade endotoxaemia in atherothrombosis and cardiovascular complications, and highlight potential therapeutic strategies to improve gut permeability and eliminate low-grade endotoxaemia.
- Francesco Violi
- , Vittoria Cammisotto
- & Cristina Nocella
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Research Highlight |
Changes to the gut microbiota drive the progression of cardiometabolic disease
Alterations to the composition of the gut microbiota are associated with changes in the levels of serum metabolites during the development of cardiometabolic disease, before the onset of overt ischaemic heart disease.
- Gregory B. Lim
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Research Highlight |
Improved gut microbiota profile in individuals with obesity taking statins
Individuals with obesity have an increased prevalence of the Bacteroides 2 enterotype, which is associated with systemic inflammation and disease. However, statin therapy is associated with a reduced prevalence of this dysbiosis in individuals with obesity.
- Gregory B. Lim
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Research Highlight |
T cells in the gut promote CVD and slow metabolism
A subset of T cells present in the small intestine modulate systemic metabolism and contribute to cardiovascular disease by limiting the bioavailability of the incretin hormone GLP1.
- Irene Fernández-Ruiz
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Review Article |
Dietary metabolism, the gut microbiome, and heart failure
Metabolites produced by gut microorganisms from dietary metabolism have been linked to the pathogenesis of heart failure, suggesting that the gut microbiome functions like an endocrine organ. In this Review, Tang and colleagues discuss the gut microbial metabolic pathways involved in heart failure and propose the gut microbiome as a therapeutic target.
- W. H. Wilson Tang
- , Daniel Y. Li
- & Stanley L. Hazen
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Correspondence |
Metabolic remodelling in heart failure revisited
- Miranda Nabben
- , Joost J. F. P. Luiken
- & Jan F. C. Glatz
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Correspondence |
Reply to ‘Metabolic remodelling in heart failure revisited’
- Edoardo Bertero
- & Christoph Maack
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News & Views |
Association between the gut microbiome and atherosclerosis
The gut microbiota has been associated with many different disorders, including cardiovascular diseases. A new study by Jie and colleagues is the first large case–control study to examine directly the enrichment of certain communities of gut bacteria in patients with atherosclerotic cardiovascular disease compared with control individuals.
- William T. Barrington
- & Aldons J. Lusis
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Correspondence |
Gastrointestinal sodium absorption, microbiome, and hypertension
- Ricardo S. Mishima
- , Adrian D. Elliott
- & Dominik Linz
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Review Article |
Beyond gut feelings: how the gut microbiota regulates blood pressure
A growing body of evidence supports the role of the gut microbiota in regulating blood pressure. In their Review, Marques and co-workers describe how the gut microbiota and its metabolites act on downstream cellular targets to influence the pathogenesis of hypertension. Novel strategies to modify the gut microbiota might present a new therapeutic avenue to improve health and prevent disease.
- Francine Z. Marques
- , Charles R. Mackay
- & David M. Kaye
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Review Article |
Role of gut microbiota in atherosclerosis
Microorganisms that populate the human body have been shown to be involved in metabolic and cardiovascular disorders, but the precise mechanisms are not completely understood. In this Review, Lindskog Jonsson and Bäckhed describe the different pathways by which the gut microbiota might affect the development of atherosclerosis.
- Annika Lindskog Jonsson
- & Fredrik Bäckhed
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Research Highlight |
Gut microbes modulate platelet function and thrombosis risk
- Irene Fernández-Ruiz
Targeting the gut to protect the heart
Microbial-dependent TMAO as a prognostic marker in ACS