Featured
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Article |
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Simultaneous widefield calcium imaging and fMRI provide insight into neural activity at multiple scales and can be used to decipher the cellular origin of BOLD activity.
- Evelyn M. R. Lake
- , Xinxin Ge
- & R. Todd Constable
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Article |
A temporal decomposition method for identifying venous effects in task-based fMRI
Temporal decomposition through manifold fitting (TDM) is an analysis technique that decomposes blood oxygenation level dependent (BOLD) responses in task-based fMRI into different components that likely correspond to microvasculature- and macrovasculature-driven signals.
- Kendrick Kay
- , Keith W. Jamison
- & Kamil Uğurbil
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Brief Communication |
A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution
A miniaturized NMR-on-a-chip needle can be implanted into rodent brains and can measure blood flow and oxygenation changes in vivo in a small volume at an unprecedentedly high temporal resolution of a few milliseconds.
- Jonas Handwerker
- , Marlon Pérez-Rodas
- & Klaus Scheffler
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Brief Communication |
Sensory and optogenetically driven single-vessel fMRI
High-field fMRI with single-vessel resolution allows one to decipher the contribution of different types of vessels to hemodynamic activity evoked by sensory or optogenetic stimulation in the rat brain.
- Xin Yu
- , Yi He
- & Alan P Koretsky
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Brief Communication |
Deciphering laminar-specific neural inputs with line-scanning fMRI
A line-scanning method is applied to obtain onset times of fMRI responses in rats. The authors show that onset time of the fMRI response can be used to infer information about which cortical layers receive the connectivity input from other brain areas.
- Xin Yu
- , Chunqi Qian
- & Alan P Koretsky
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Review Article |
Imaging human connectomes at the macroscale
At macroscopic scales, the human connectome comprises anatomically distinct brain areas, the structural pathways connecting them and their functional interactions. Annotation of phenotypic associations with variation in the connectome and cataloging of neurophenotypes promise to transform our understanding of the human brain. In this Review, we provide a survey of magnetic resonance imaging–based measurements of functional and structural connectivity. We highlight emerging areas of development and inquiry and emphasize the importance of integrating structural and functional perspectives on brain architecture.
- R Cameron Craddock
- , Saad Jbabdi
- & Michael P Milham
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Editorial |
fMRI: a tree with fuzzy roots
A deeper understanding of the mechanisms underlying functional magnetic resonance imaging signals is crucial for maximizing the return on human fMRI research.
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News & Views |
Shedding light on the BOLD fMRI response
Fluorescence recording of neural activity in the magnetic resonance scanner is a new strategy for examining the cellular underpinnings of blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI).
- Serge Charpak
- & Bojana Stefanovic
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Article |
Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex
Simultaneous functional magnetic resonance imaging (fMRI) and fiber-optic–based calcium recordings in rats allow investigation of the relationship between blood oxygen level–dependent (BOLD) fMRI signals and the underlying neural activity. The study uncovers prolonged BOLD signal components involving glial activation.
- Kristina Schulz
- , Esther Sydekum
- & Fritjof Helmchen
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News & Views |
Establishing homology between monkey and human brains
Neuroimaging methods are beginning to provide promising ways of understanding the functional organization of the brain across species.
- Tor D Wager
- & Tal Yarkoni
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Article |
Interspecies activity correlations reveal functional correspondence between monkey and human brain areas
To examine functional correspondences between monkey and human brain areas, a method based on the temporal correlation of sensory-evoked functional magnetic resonance imaging responses is proposed. The study reveals putative homologous regions that have shifted to topologically unexpected locations during evolution.
- Dante Mantini
- , Uri Hasson
- & Wim Vanduffel
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Research Highlights |
Collective brain maps
A new study, pooling brain-imaging data from 35 centers across the world, shows the power of data sharing and demonstrates a universal architecture of functional connections in the human brain.
- Erika Pastrana
Next-generation MRI scanner designed for ultra-high-resolution human brain imaging at 7 Tesla