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| Open AccessFluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators
- Osha Roopnarine
- , Samantha L. Yuen
- & David D. Thomas
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| Open AccessIntegrating GWAS and proteome data to identify novel drug targets for MU
- Yadong Wu
- , Jukun Song
- & Junmei Zhang
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| Open AccessAn interaction-based drug discovery screen explains known SARS-CoV-2 inhibitors and predicts new compound scaffolds
- Philipp Schake
- , Klevia Dishnica
- & Michael Schroeder
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| Open AccessEbselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
- Mikolaj Zmudzinski
- , Wioletta Rut
- & Marcin Drag
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| Open AccessAnti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract
- Homa Nath Sharma
- , Jonathan Catrett
- & Daniel A. Abugri
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| Open AccessComparing the effects of four common drug classes on the progression of mild cognitive impairment to dementia using electronic health records
- Jie Xu
- , Fei Wang
- & Jyotishman Pathak
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| Open AccessUltrasound-Promoted preparation and application of novel bifunctional core/shell Fe3O4@SiO2@PTS-APG as a robust catalyst in the expeditious synthesis of Hantzsch esters
- Peyman Shakib
- , Mohammad G. Dekamin
- & Mohammad Dohendou
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| Open AccessDesign, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives
- Yuanfang Kong
- , Shuanglin Liu
- & Chunhong Dong
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| Open AccessScaffold repositioning of spiro-acridine derivatives as fungi chitinase inhibitor by target fishing and in vitro studies
- Jéssika de Oliveira Viana
- , Eden Silva e Souza
- & Euzébio Guimarães Barbosa
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| Open AccessMasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference
- Olanrewaju Ayodeji Durojaye
- , Nkwachukwu Oziamara Okoro
- & Bennett Chima Nwanguma
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| Open AccessPredicting drug adverse effects using a new Gastro-Intestinal Pacemaker Activity Drug Database (GIPADD)
- Julia Yuen Hang Liu
- & John A. Rudd
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| Open AccessIn vitro PCR verification that lysozyme inhibits nucleic acid replication and transcription
- Lu Liu
- , Xu Jia
- & Qian Zheng
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| Open AccessSimultaneous green TLC determination of nirmatrelvir and ritonavir in the pharmaceutical dosage form and spiked human plasma
- Mohamed S. Imam
- , Ahmed H. Abdelazim
- & Tamer H. A. Hasanin
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| Open AccessDrug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c
- Andrew Dimond
- , Mathew Van de Pette
- & Amanda G. Fisher
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| Open AccessAn ultra-high-throughput screen for the evaluation of peptide HLA-Binder interactions
- Stefan Krämer
- , Andreas Moritz
- & Johannes Wöhrle
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| Open AccessDiscovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays
- Priyanka Parijat
- , Saraswathi Ponnam
- & Thomas Kampourakis
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| Open AccessFast calculation of hydrogen-bond strengths and free energy of hydration of small molecules
- Gian Marco Ghiandoni
- & Eike Caldeweyher
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| Open AccessIn silico assessment on TdP risks of drug combinations under CiPA paradigm
- Ali Ikhsanul Qauli
- , Aroli Marcellinus
- & Ki Moo Lim
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| Open AccessHigher throughput workflow with sensitive, reliable and automatic quantification of myelination in vitro suitable for drug screening
- Sybille Seiler
- , Ciril Marius Wälti
- & Lynette C. Foo
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| Open Access1′-O-methyl-averantin isolated from the endolichenic fungus Jackrogersella sp. EL001672 suppresses colorectal cancer stemness via sonic Hedgehog and Notch signaling
- Mücahit Varlı
- , Eun-Young Lee
- & Hangun Kim
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| Open AccessCharacterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α
- Mohamed Ismail
- , Stephen R. Martin
- & Julian Downward
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| Open AccessVirtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants Spike protein/ACE2 interface
- Davide Pirolli
- , Benedetta Righino
- & Maria Cristina De Rosa
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| Open AccessIn silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor
- Asma Gholami
- , Dariush Minai-Tehrani
- & Leif A. Eriksson
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| Open AccessEstablishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs
- Ryu Kawada
- , Tatsuya Jonouchi
- & Hidetoshi Sakurai
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| Open AccessMechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
- Francesca Margara
- , Yiangos Psaras
- & Alfonso Bueno-Orovio
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| Open AccessQuantitative structure–activity relationship modeling for predication of inhibition potencies of imatinib derivatives using SMILES attributes
- Hamideh Hamzehali
- , Shahram Lotfi
- & Parvin Kumar
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| Open AccessAn efficient human stem cells derived cardiotoxicity testing platform for testing oncotherapeutic analogues of quercetin and cinnamic acid
- Saurabh Mandal
- , Naisarg Gamit
- & Sudha Warrier
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| Open AccessEfficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration
- Kenichi Mishima
- , Yuka Tsukagoshi Okabe
- & Shiro Imagama
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| Open AccessSuccinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning
- Sarah Piel
- , Joanna I. Janowska
- & Todd J. Kilbaugh
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| Open AccessOptimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs
- Sang-Yun Lee
- , Hyun Ju Hwang
- & Dong Woo Lee
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| Open AccessThe use of machine learning modeling, virtual screening, molecular docking, and molecular dynamics simulations to identify potential VEGFR2 kinase inhibitors
- Abbas Salimi
- , Jong Hyeon Lim
- & Jin Yong Lee
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| Open AccessNeuroprotective metabolites via fungal biotransformation of a novel sapogenin, cyclocephagenol
- Melis Küçüksolak
- , Göklem Üner
- & Erdal Bedir
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| Open AccessDiscovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor
- Gustavo Fernando Mercaldi
- , Eduardo Henrique Salviano Bezerra
- & Daniela Barretto Barbosa Trivella
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| Open AccessThe effectiveness of immunomodulatory therapies for patients with repeated implantation failure: a systematic review and network meta-analysis
- Mengqi Liu
- , Yuan Yuan
- & Dongzi Yang
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| Open AccessReduction of stress responses in honey bees by synthetic ligands targeting an allatostatin receptor
- Adrià Sánchez-Morales
- , Véronique Gigoux
- & Jean-Marc Devaud
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| Open AccessSilymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats
- Rahman Karimi
- , Ali Bakhshi
- & Seyed Morteza Naghib
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| Open AccessDYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
- Bangfu Zhu
- , Tom Parsons
- & James J. L. Hodge
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| Open AccessNeuroprotective potential of Cannabis sativa-based oils in Caenorhabditis elegans
- Ana Paula Vanin
- , Wagner Antonio Tamagno
- & Rosilene Rodrigues Kaizer
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| Open AccessA new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
- Deniz Cansen Kahraman
- , Ebru Bilget Guven
- & Rengul Cetin Atalay
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| Open AccessNovel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening
- Anuradha Kumar
- , Somsundaram Chettiar
- & Tanya Parish
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| Open AccessIdentification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
- Eric R. Goedken
- , Maria A. Argiriadi
- & Chaohong Sun
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| Open AccessAutomated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor
- Antonio N. Mauro
- , Paul J. Turgeon
- & Krishna K. Singh
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| Open AccessAlpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models
- Eunhye Yu
- , Yunjeong Song
- & Jaesuk Yun
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| Open AccessVerteporfin ameliorates fibrotic aspects of Dupuytren’s disease nodular fibroblasts irrespective the activation state of the cells
- Nataly Puerta Cavanzo
- , Sophie A. Riesmeijer
- & Ruud A. Bank
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| Open AccessIdentification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study
- Adam Hermawan
- , Febri Wulandari
- & Ahmad Syauqy Tafrihani
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| Open AccessIdentification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus
- Deepika Chaudhary
- , Avantika Singh
- & Ramandeep Singh
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| Open AccessAbsolute binding free energy calculations improve enrichment of actives in virtual compound screening
- Mudong Feng
- , Germano Heinzelmann
- & Michael K. Gilson
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| Open AccessFunctional human cell-based vascularised cardiac tissue model for biomedical research and testing
- Maria Koivisto
- , Tuomas A. Tolvanen
- & Tuula Heinonen
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| Open AccessTargeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysis
- Ibrahim M. Ibrahim
- , Abdo A. Elfiky
- & Mahmoud ElHefnawi