Featured
-
-
Review Article
| Open Access
Recent advances in extracellular vesicles for therapeutic cargo delivery
- Hyo In Kim
- , Jinbong Park
- & Duo Zhang
-
Article
| Open Access
Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser
- Hoyoung Kim
- , Taehyun Lim
- & Hyun-Soo Cho
-
-
Review Article
| Open Access
Peptides as multifunctional players in cancer therapy
- Sri Murugan Poongkavithai Vadevoo
- , Smriti Gurung
- & Byungheon Lee
-
Review Article
| Open Access
Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics
- Yeaeun Han
- & Sung Young Kim
-
Article
| Open Access
Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases
- Bin Wang
- , Xuheng Chen
- & Ming Cui
-
Article
| Open Access
Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin–p65 interaction
- Junhyeong Yim
- , Jaeseok Lee
- & Seung Bum Park
-
Review Article
| Open Access
Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
- Jong Hyun Kim
- , Chan-Hyeong Lee
- & Moon-Chang Baek
-
Article
| Open Access
An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies
- Sanghwan Ko
- , Sora Park
- & Sang Taek Jung
-
Article
| Open Access
Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling
- Chunlei Liu
- , Peng Li
- & Zhongmin Zhang
-
Article
| Open Access
Preclinical investigation of artesunate as a therapeutic agent for hepatocellular carcinoma via impairment of glucosylceramidase-mediated autophagic degradation
- Wenjia Chen
- , Zhaochen Ma
- & Yanqiong Zhang
-
Article
| Open Access
Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
- Debra Dorotea
- , Songling Jiang
- & Hunjoo Ha
-
Article
| Open Access
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
- Guodong Li
- , Dan Li
- & Chung-Hang Leung
-
Article
| Open Access
Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
- Guo Nan Yin
- , Do-Kyun Kim
- & Ho Min Kim
-
Review Article
| Open Access
RNA therapy: rich history, various applications and unlimited future prospects
- Young-Kook Kim
-
Article
| Open Access
Fibrinolytic nanocages dissolve clots in the tumor microenvironment, improving the distribution and therapeutic efficacy of anticancer drugs
- Junyoung Seo
- , Jae Do Yoo
- & Soyoun Kim
-
Review Article
| Open Access
Organoids in image-based phenotypic chemical screens
- Ilya Lukonin
- , Marietta Zinner
- & Prisca Liberali
-
Article
| Open Access
A human antibody against human endothelin receptor type A that exhibits antitumor potency
- Man-Seok Ju
- , Hye-Mi Ahn
- & Sang Taek Jung
-
Article
| Open Access
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair
- Ji Hye Park
- , Hyeok Kim
- & Sang-Mo Kwon
-
Review Article
| Open Access
Aurora kinase A, a synthetic lethal target for precision cancer medicine
- Pui Kei Mou
- , Eun Ju Yang
- & Joong Sup Shim
-
Review Article
| Open Access
Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
- Yongwoo Jang
- , Woori Kim
- & Kwang-Soo Kim
-
Review Article
| Open Access
Live biotherapeutic products: the importance of a defined regulatory framework
- Magali Cordaillat-Simmons
- , Alice Rouanet
- & Bruno Pot
-
Article
| Open Access
Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy
- Nicolas Taveau
- , Aurélie Cubizolle
- & Philippe Brabet
-
Review Article
| Open Access
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
- Youn-Sang Jung
- & Jae-Il Park
-
Article
| Open Access
Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer
- Kai Xiong
- , Hejun Zhang
- & Shigang Ding
-
Article
| Open Access
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure−activity relationship with a strong BBB permeability
- Susoma Jannat
- , Anand Balupuri
- & Gil Hong Park
-
Article
| Open Access
A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles
- Sehyun Chae
- , Su-Jin Kim
- & Kyong Soo Park
-
Article
| Open Access
Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300
- Pradeep K. Sacitharan
- , Seint Lwin
- & James R. Edwards
-
Article
| Open Access
Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models
- Young Cheol Kang
- , Minuk Son
- & Youngmi Kim Pak
-
Article
| Open Access
An MG53-IRS1-interaction disruptor ameliorates insulin resistance
- Jun Sub Park
- , Hyun Lee
- & Young-Gyu Ko
-
-
Article
| Open Access
Therapeutic potential of a phospholipase D1 inhibitory peptide fused with a cell-penetrating peptide as a novel anti-asthmatic drug in a Der f 2-induced airway inflammation model
- Yun Young Lee
- , So Young Lee
- & Joong-Soo Han
-
Original Article
| Open Access
Nanocurcumin–pyrroloquinoline formulation prevents hypertrophy–induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions
- Sarita Nehra
- , Varun Bhardwaj
- & Deepika Saraswat
-
Original Article
| Open Access
Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity
- Sun Hong Park
- , Jeong-Ah Kwak
- & Youngsoo Kim
-
Review
| Open AccessMuscle fatigue: general understanding and treatment
- Jing-jing Wan
- , Zhen Qin
- & Xia Liu
-
Original Article
| Open Access
Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits
- Sergio Bárcena-Varela
- , Guillermo Martínez-de-Tejada
- & Lena Heinbockel
-
-
Original Article
| Open Access
Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo
- Ke Yang
- , Yifan Chen
- & Liwu Fu
-
Original Article
| Open Access
GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processes
- Sang-Hoon Kim
- , Hyun-Jung Kim
- & Chan-Wha Kim
Exploiting sweet relief for preeclampsia by targeting autophagy-lysosomal machinery and proteinopathy
Heteromerization of μ-opioid receptor and cholecystokinin B receptor through the third transmembrane domain of the μ-opioid receptor contributes to the anti-opioid effects of cholecystokinin octapeptide
Affibody molecules as engineered protein drugs