One of the major challenges in IBD therapy is targeting delivery of the drug to the specific site of inflammation. A recent approach to combat this problem is the use of nanoparticulate drug delivery systems that selectively accumulate a given drug at the site of affected tissue. As the drug load is delivered locally, drug dose and adverse effects are reduced.
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Lamprecht, A. Selective nanoparticle adhesion can enhance colitis therapy. Nat Rev Gastroenterol Hepatol 7, 311–312 (2010). https://doi.org/10.1038/nrgastro.2010.66
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DOI: https://doi.org/10.1038/nrgastro.2010.66
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