DNA methylation

DNA methylation is the covalent addition of methyl groups to DNA bases, typically the cytosine of CpG dinucleotides. It is catalyzed by methyltransferase enzymes using a S-adenosyl methionine donor and can lead to mitotic propagation of the modified sequence with consequences for the binding of regulatory proteins such as transcription factors.

Latest Research and Reviews

  • Research | | open

    Epigenetic control of enhancers may contribute to neurological disease. Here the authors carry out genome-wide analysis of DNA methylation in neurons isolated postmortem from patients with Alzheimer’s disease.

    • Peipei Li
    • , Lee Marshall
    • , Gabriel Oh
    • , Jennifer L. Jakubowski
    • , Daniel Groot
    • , Yu He
    • , Ting Wang
    • , Arturas Petronis
    •  & Viviane Labrie
  • Research | | open

    N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked pioneer factor zelda.

    • Shunmin He
    • , Guoqiang Zhang
    • , Jiajia Wang
    • , Yajie Gao
    • , Ruidi Sun
    • , Zhijie Cao
    • , Zhenping Chen
    • , Xiudeng Zheng
    • , Jiao Yuan
    • , Yuewan Luo
    • , Xiaona Wang
    • , Wenxin Zhang
    • , Peng Zhang
    • , Yi Zhao
    • , Chuan He
    • , Yi Tao
    • , Qinmiao Sun
    •  & Dahua Chen
  • Research |

    A single-cell approach is used to follow the heritable stochastic changes to DNA methylation that occur in primary chronic lymphocytic leukaemia and healthy B cells, allowing the tracing of cell lineage histories and evolution during treatment with ibrutinib.

    • Federico Gaiti
    • , Ronan Chaligne
    • , Hongcang Gu
    • , Ryan M. Brand
    • , Steven Kothen-Hill
    • , Rafael C. Schulman
    • , Kirill Grigorev
    • , Davide Risso
    • , Kyu-Tae Kim
    • , Alessandro Pastore
    • , Kevin Y. Huang
    • , Alicia Alonso
    • , Caroline Sheridan
    • , Nathaniel D. Omans
    • , Evan Biederstedt
    • , Kendell Clement
    • , Lili Wang
    • , Joshua A. Felsenfeld
    • , Erica B. Bhavsar
    • , Martin J. Aryee
    • , John N. Allan
    • , Richard Furman
    • , Andreas Gnirke
    • , Catherine J. Wu
    • , Alexander Meissner
    •  & Dan A. Landau
    Nature, 1-5
  • Research | | open

    Master transcription factors dominantly direct cell fate and barriers ensuring their tissue specific silencing are not clearly defined. Here, the authors demonstrate that inefficient targeted transactivation of Sox1 in neural progenitor cells is surmountable through targeted promoter demethylation using dCas9-Tet1.

    • Valentin Baumann
    • , Maximilian Wiesbeck
    • , Christopher T. Breunig
    • , Julia M. Braun
    • , Anna Köferle
    • , Jovica Ninkovic
    • , Magdalena Götz
    •  & Stefan H. Stricker
  • Research | | open

    Monozygotic (MZ) twins are ideal to study the influence of non-genetic factors on complex phenotypes. Here, Souren et al. perform an EWAS in peripheral blood mononuclear cells from 45 MZ twins discordant for multiple sclerosis and identify disease and treatment-associated epigenetic markers.

    • Nicole Y. Souren
    • , Lisa A. Gerdes
    • , Pavlo Lutsik
    • , Gilles Gasparoni
    • , Eduardo Beltrán
    • , Abdulrahman Salhab
    • , Tania Kümpfel
    • , Dieter Weichenhan
    • , Christoph Plass
    • , Reinhard Hohlfeld
    •  & Jörn Walter

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