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Gene silencing

Reading banned regions of genomes

Nature Plants volume 10, pages 7–8 (2024)Cite this article

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The effect of DNA methylation on gene expression has been known for decades. However, the mechanism by which DNA methylation functions to repress transcription has remained a major question in the field. Wang et al. now narrow this gap through their examination of the methylation binding protein MBD2 and expose how DNA methylation is read upstream of transcriptional repression.

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Fig. 1: Context-dependent roles of the MBD2 protein.

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Authors and Affiliations

  1. Donald Danforth Plant Science Center, St Louis, MO, USA

    Marianne C. Kramer, Ryan Swanson & R. Keith Slotkin

  2. Division of Biological Sciences, University of Missouri, Columbia, MO, USA

    Ryan Swanson & R. Keith Slotkin

Authors
  1. Marianne C. Kramer
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  2. Ryan Swanson
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  3. R. Keith Slotkin
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Correspondence to R. Keith Slotkin.

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Kramer, M.C., Swanson, R. & Slotkin, R.K. Reading banned regions of genomes. Nat. Plants 10, 7–8 (2024). https://doi.org/10.1038/s41477-023-01600-z

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