The ATP-dependent chromatin remodeller DDM1 has a vital role in plant DNA methylation, influencing gene silencing and suppression of transposable elements. The structure of DDM1 in complex with nucleosome in different states of the ATP hydrolysis process reveals the molecular mechanism underlying chromatin remodelling by DDM1.
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References
Law, J. A. & Jacobsen, S. E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat. Rev. Genet. 11, 204–220 (2010). This review article summarizes de novo DNA methylation, maintenance of DNA methylation and demethylation in plants and animals.
Akinmusola, R. Y., Wilkins, C. A. & Doughty, J. DDM1-Mediated TE silencing in plants. Plants (Basel) 12, 437 (2023). A review article summarizing the function of DDM1 in transposable elements suppression.
Zemach, A. et al. The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin. Cell 153, 193–205 (2013). This paper showed that DDM1 overcomes H1 binding for DNA methyltransferase accessibility.
Osakabe, A. et al. The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W. Nat. Cell Biol. 23, 391–400 (2021). This paper showed that DDM1 might suppress transposable elements by changing the properties of chromatin by depositing H2A.W.
Shang, J. Y. & He, X. J. Chromatin-remodeling complexes: Conserved and plant-specific subunits in. Arabidopsis. J. Integr. Plant Biol. 64, 499–515 (2022). A review article summarizing the properties and compositions of plant chromatin remodellers.
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This is a summary of: Liu, Y. et al. Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat. Plants https://doi.org/10.1038/s41477-024-01640-z (2024).
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Cryo-EM structures reveal the chromatin remodelling mechanism of DDM1. Nat. Plants 10, 358–359 (2024). https://doi.org/10.1038/s41477-024-01653-8
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DOI: https://doi.org/10.1038/s41477-024-01653-8
