Diseases of the nervous system articles within Nature Chemistry

Featured

• Article | 03 April 2017

  A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells

  The self-propagation of misfolded conformations of tau occurs in neurodegenerative diseases, including Alzheimer's disease. The microtubule-binding region, tau_244-372, reproduces much of the aggregation behaviour of tau in cells and animal models. Now, it has been shown that a 31-residue peptide from tau's R3 domain forms a cross-β conformation that efficiently seeds aggregation of tau_244-372 in cells.

  • Jan Stöhr
  • , Haifan Wu
  •  & William F. DeGrado

• Research Highlights | 26 November 2010

  Binding screens

  Small-molecule microarrays facilitate the search for Alzheimer's disease therapeutics by screening compounds that bind to the amyloid-β peptide.

  • Anne Pichon

• Thesis | 01 July 2010

  Hydrophobia!

  As we learn more about the complexities of water, Bruce Gibb argues that organic chemists shouldn't be afraid to take the plunge into aqueous environments.

  • Bruce C. Gibb