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News & Views |
A 3D boost
Biophysical factors in an optimized three-dimensional microenvironment enhance the reprogramming efficiency of human somatic cells into pluripotent stem cells when compared to traditional cell-culture substrates.
- Oscar J. Abilez
- & Joseph C. Wu
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News & Views |
Roll-on scaffolds
A spool-and-ribbon cell-culture approach provides quick and easy access to the interior of engineered tumours for the analysis of cell responses to molecular gradients.
- Peter DelNero
- & Claudia Fischbach
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News & Views |
Yielding substrates for neurons
Soft culture substrates improve the yield of functional motor neurons derived from human pluripotent stem cells.
- Emily Rhodes Lowry
- & Christopher E. Henderson
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News & Views |
Anchoring cell-fate cues
The spreading and differentiation of stem cells depends on the stiffness of the extracellular matrix. Now, experiments on human epidermal and mesenchymal stem cells cultured on substrates with covalently attached collagen fibres show that the cells sense and respond to the anchoring of the collagen fibres to the substrate.
- Ovijit Chaudhuri
- & David J. Mooney
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News & Views |
Multipotency retained
Stem cells that are cultured in the laboratory differentiate in response to the mechanical properties of the substrate and its topography. It is now shown that mesenchymal stem cell multipotency is prolonged when the cells are cultured on a surface patterned with an ordered arrangement of nanoscale pits.
- Milan Mrksich
Shape-based separation of synthetic microparticles