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Stem cell reprogramming

A 3D boost

Nature Materials volume 15, pages 259–261 (2016)Cite this article

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Biophysical factors in an optimized three-dimensional microenvironment enhance the reprogramming efficiency of human somatic cells into pluripotent stem cells when compared to traditional cell-culture substrates.

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Figure 1: 3D iPSC generation.
Figure 2: High-throughput screening approach to optimize iPSC reprogramming efficiency.

References

  1. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  Google Scholar 

  2. Wilson, K. D. & Wu, J. C. JAMA 313, 1613–1614 (2015).

    Article  Google Scholar 

  3. Caiazzo, M. et al. Nature Mater. 15, 344–352 (2016).

    Article  CAS  Google Scholar 

  4. Lutolf, M. P. & Hubbell, J. A. Nature Biotech. 23, 47–55 (2005).

    Article  CAS  Google Scholar 

  5. Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Cell 126, 677–689 (2006).

    Article  CAS  Google Scholar 

  6. Chowdhury, F. et al. Nature Mater. 9, 82–88 (2010).

    Article  CAS  Google Scholar 

  7. Ranga, A. et al. Nature Commun. 5, 4324 (2014).

    Article  CAS  Google Scholar 

  8. Downing, T. L. et al. Nature Mater. 12, 1154–1162 (2013).

    Article  CAS  Google Scholar 

  9. Lei, Y. & Schaffer, D. V. Proc. Natl Acad. Sci. USA 110, E5039–E5048 (2013).

    Article  CAS  Google Scholar 

  10. Howden, S. E. et al. Stem Cell Rep. 5, 1109–1118 (2015).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Department of Medicine, Oscar J. Abilez and Joseph C. Wu are at the Stanford Cardiovascular Institute, and the Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA,

    Oscar J. Abilez & Joseph C. Wu

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  1. Oscar J. Abilez
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  2. Joseph C. Wu
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Correspondence to Oscar J. Abilez or Joseph C. Wu.

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Abilez, O., Wu, J. A 3D boost. Nature Mater 15, 259–261 (2016). https://doi.org/10.1038/nmat4583

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