Research Highlight |
Featured
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Research Highlight |
Spotlight on Cas12
A search for more type V Cas12 family members turns up unexpected functionality.
- Nicole Rusk
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Research Highlight |
Recording transcriptional activity
Acquisition of RNA into CRISPR arrays allows the recording of transcriptional dynamics in cells.
- Nicole Rusk
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Research Highlights |
Imaging allelic loci in live cells
SNP-CLING enables determining the dynamics of alleles on different chromosomes in live cells.
- Nina Vogt
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Research Highlights |
How phages defeat CRISPR
As more phage-derived Cas9 inhibitors are discovered, their detailed characterization is a prerequisite to using them as research tools.
- Nicole Rusk
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Tools in Brief |
Single-base editing
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Research Highlights |
Another player for RNA-guided RNA cleavage
Cas13b relies on activator and repressor proteins to regulate RNA cleavage.
- Nicole Rusk
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Tools in Brief |
CRISPR screens tackle the noncoding genome
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Research Highlights |
REXER helps design bacterial genomes
A CRISPR–Cas9-based approach identifies synonymous codons that can be reassigned to encode new chemical building blocks.
- Nicole Rusk
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Tools in Brief |
Showdown between Cas9 and Cpf1
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Research Highlights |
Retraining an editor as a mapmaker
A sequence-specific labeling system based on CRISPR/Cas9 enables simultaneous imaging of multiple chromosomal sites in live cells.
- Michael Eisenstein
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Research Highlights |
Cas9 and the importance of asymmetry
Short single-stranded DNA donors that asymmetrically span the Cas9 cut site show high efficiency in homology-directed editing.
- Nicole Rusk
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Tools in Brief |
Cas9 on target
