CRISPR-Cas9 genome editing articles within Nature Methods

Featured

• In Brief | 27 June 2019

  CRISPR inhibitors

  • Nicole Rusk

• In Brief | 28 March 2019

  Human immunity to Cas9

  • Nicole Rusk

• In Brief | 27 February 2019

  Inhibiting CRISPR

  • Nicole Rusk

• Research Highlight | 27 February 2019

  Spotlight on Cas12

  A search for more type V Cas12 family members turns up unexpected functionality.

  • Nicole Rusk

• In Brief | 30 November 2018

  Protein-based cell barcodes

  • Tal Nawy

• In Brief | 01 October 2018

  Better base editors

  • Nicole Rusk

• In Brief | 31 August 2018

  CRISPR and immunity

  • Nicole Rusk

• Research Highlights | 01 December 2017

  Evolution of an A-base editor

  Protein evolution yields a programmable base editor that can revert the most common pathogenic point mutations in the genome.

  • Tal Nawy

• Tools in Brief | 31 October 2017

  Hyper-accurate Cas9

• Research Highlights | 29 September 2017

  How phages defeat CRISPR

  As more phage-derived Cas9 inhibitors are discovered, their detailed characterization is a prerequisite to using them as research tools.

  • Nicole Rusk

• Methods in Brief | 01 September 2017

  Limits of gene drives

• Research Highlights | 01 September 2017

  What comes first—genomic structure or function?

  CRISPR-mediated chromatin looping provides insight into the effect of genomic structure on gene expression.

  • Nicole Rusk

• Tools in Brief | 29 June 2017

  Self-limiting Cas9

• Research Highlights | 29 June 2017

  CRISPR kinetics

  In vitro Cas9-binding assays show the effects of mutations in the target sequence on binding kinetics.

  • Nicole Rusk

• Tools in Brief | 31 March 2017

  Single-base editing

• Research Highlights | 28 February 2017

  Another player for RNA-guided RNA cleavage

  Cas13b relies on activator and repressor proteins to regulate RNA cleavage.

  • Nicole Rusk

• Tools in Brief | 29 November 2016

  CRISPR screens tackle the noncoding genome

• Research Highlights | 29 November 2016

  REXER helps design bacterial genomes

  A CRISPR–Cas9-based approach identifies synonymous codons that can be reassigned to encode new chemical building blocks.

  • Nicole Rusk

• Methods in Brief | 31 October 2016

  Apicomplexans submit to CRISPR screening

• Tools in Brief | 30 August 2016

  Showdown between Cas9 and Cpf1

• Research Highlights | 28 July 2016

  Cas9, the cellular genealogist

  Genome editing marks cells in developing fish for lineaging studies.

  • Tal Nawy

• Research Highlights | 31 May 2016

  Retraining an editor as a mapmaker

  A sequence-specific labeling system based on CRISPR/Cas9 enables simultaneous imaging of multiple chromosomal sites in live cells.

  • Michael Eisenstein

• Research Highlights | 30 March 2016

  Cas9 and the importance of asymmetry

  Short single-stranded DNA donors that asymmetrically span the Cas9 cut site show high efficiency in homology-directed editing.

  • Nicole Rusk

• Tools in Brief | 25 February 2016

  Cas9 on target

• Research Highlights | 28 January 2016

  Driving out malaria

  Laboratory tests show that gene drives could obliterate wild mosquito populations carrying the malaria parasite, or make them resistant to its transmission.

  • Tal Nawy

• Tools in Brief | 30 June 2015

  Efficient transduction of proteins into eukaryotic cells

• News & Views | 30 June 2015

  Co-opting CRISPR to deliver functional RNAs

  Portions of the CRISPR-Cas9 guide RNA can be reworked to carry functional RNA cargos to genomic loci.

  • Pei-Chun Lin
  •  & Jacob E Corn