Cell growth articles within Nature Methods

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• News & Views | 03 May 2021

  A small-molecule cocktail that beats cellular stress

  CEPT, a small-molecule cocktail, improves the viability of human pluripotent stem cells, protects cells during culture and cryopreservation, and promotes in vitro differentiation and organoid formation.

  • Rajarshi Pal

• In Brief | 28 November 2019

  Culturing HSPCs

  • Arunima Singh

• Article | 11 February 2019

  Noninvasive monitoring of single-cell mechanics by acoustic scattering

  Acoustic scattering in a suspended microchannel resonator can be used to measure mechanical properties of single cells in a noninvasive manner. The approach is applied to follow stiffness changes of individual cells throughout the cell cycle.

  • Joon Ho Kang
  • , Teemu P. Miettinen
  •  & Scott R. Manalis

• Article | 05 March 2018

  Using deep learning to model the hierarchical structure and function of a cell

  Embedding a deep-learning model in the known structure of cellular systems yields DCell, a ‘visible’ neural network that can be used to mechanistically interpret genotype–phenotype relationships.

  • Jianzhu Ma
  • , Michael Ku Yu
  •  & Trey Ideker

• Article | 28 August 2017

  Oscillatory stimuli differentiate adapting circuit topologies

  Negative feedback and incoherent feed-forward loops are the only circuit motifs that can adapt in response to stimuli. Rahi et al. describe signatures that allow discriminating between these two motifs and demonstrate the approach in yeast cell cycle timing and C. elegans olfaction.

  • Sahand Jamal Rahi
  • , Johannes Larsch
  •  & Frederick R Cross

• Perspective | 25 November 2014

  Live-cell mass profiling: an emerging approach in quantitative biophysics

  This Perspective discusses methods to measure single-cell mass and their relative strengths and weaknesses for different applications.

  • Thomas A Zangle
  •  & Michael A Teitell

• Research Highlights | 30 January 2014

  Screening CRISPly in human cells

  Two groups demonstrate the use of the CRISPR-Cas9 system for genetic screens in human cells.

  • Natalie de Souza

• Brief Communication | 05 August 2012

  Direct observation of mammalian cell growth and size regulation

  Precise mass measurement on single mammalian cells is combined with imaging to monitor changes in cellular mass during the cell cycle over many generations.

  • Sungmin Son
  • , Amit Tzur
  •  & Scott R Manalis

• Brief Communication | 01 August 2010

  Automated imaging with ScanLag reveals previously undetectable bacterial growth phenotypes

  A simple automated system to simultaneously measure growth rate and lag time of large numbers of bacteria permits the identification of subsets in a heterogenous population.

  • Irit Levin-Reisman
  • , Orit Gefen
  •  & Nathalie Q Balaban

• News & Views | 01 May 2010

  Measuring the growth rate of cells, one at a time

  Silicon-based microscales allow real-time measurements of the growth rate of single cells and open up interesting perspectives for the study of mass biogenesis at the cellular level.

  • Gilles Charvin

• Brief Communication | 11 April 2010

  Using buoyant mass to measure the growth of single cells

  A microfluidic device containing a suspended microchannel resonator capable of measuring the mass of microscopic objects with femtogram resolution allows determination of bacteria, yeast and mammalian cell growth rates in less than one cell cycle by repeated measurement of the buoyant mass of single growing cells.

  • Michel Godin
  • , Francisco Feijó Delgado
  •  & Scott R Manalis