Featured
-
-
Article
| Open Access
A new prediction nomogram of non-sentinel lymph node metastasis in cT1-2 breast cancer patients with positive sentinel lymph nodes
- Liu Yang
- , Xueyi Zhao
- & Zhenchuan Song
-
Article
| Open Access
A pancreatic cancer organoid-in-matrix platform shows distinct sensitivities to T cell killing
- Anton Lahusen
- , Jierui Cai
- & Yuan-Na Lin
-
Article
| Open Access
Malignant features of minipig melanomas prior to spontaneous regression
- Héloïse Débare
- , Fany Blanc
- & Giorgia Egidy
-
Article
| Open Access
NET-related gene signature for predicting AML prognosis
- Jiajia Wang
- , Huiping Wang
- & Zhimin Zhai
-
Article
| Open Access
Tumor promoting effect of spheroids in an orthotopic prostate cancer mouse model
- Julius Lars Daniel Bastian
- , Philip Zeuschner
- & Johannes Linxweiler
-
Article
| Open Access
Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice
- Mary Esmeralda Fuentes
- , Xiaoyin Lu
- & Pawel K. Mazur
-
Article
| Open Access
The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland
- Serena Martinelli
- , Giulia Cantini
- & Michaela Luconi
-
Article
| Open Access
A distributed feature selection pipeline for survival analysis using radiomics in non-small cell lung cancer patients
- Benedetta Gottardelli
- , Varsha Gouthamchand
- & Andrea Damiani
-
Article
| Open Access
Identification of molecular subtypes and a prognostic signature based on m6A/m5C/m1A-related genes in lung adenocarcinoma
- Yu Zhang
- , Qiuye Jia
- & Li Bian
-
Article
| Open Access
Podocalyxin promotes the formation of compact and chemoresistant cancer spheroids in high grade serous carcinoma
- Ngoc Le Tran
- , Yao Wang
- & Guiying Nie
-
Article
| Open Access
Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation
- Angela Florio
- , Sarah Johnson
- & George Vasmatzis
-
Article
| Open Access
The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer
- Giulia Trimaglio
- , Tamara Sneperger
- & Yoann Rombouts
-
Article
| Open Access
Unbiased serum metabolomic analysis in cats with naturally occurring chronic enteropathies before and after medical intervention
- Maria Questa
- , Bart C. Weimer
- & Sina Marsilio
-
Article
| Open Access
Male manipulation impinges on social-dependent tumor suppression in Drosophila melanogaster females
- Perla Akiki
- , Pierre Delamotte
- & Jacques Montagne
-
Article
| Open Access
A novel tumor-associated neutrophil gene signature for predicting prognosis, tumor immune microenvironment, and therapeutic response in breast cancer
- Jianyou Zhang
- , Xinbo Wang
- & Feng Wang
-
Article
| Open Access
Elucidating hepatocellular carcinoma progression: a novel prognostic miRNA–mRNA network and signature analysis
- Fei Wang
- , Xichun Kang
- & Huimin Yan
-
Article
| Open Access
Development of a promising PPAR signaling pathway-related prognostic prediction model for hepatocellular carcinoma
- Qingmiao Shi
- , Yifan Zeng
- & Lanjuan Li
-
Article
| Open Access
Exploration and machine learning model development for T2 NSCLC with bronchus infiltration and obstructive pneumonia/atelectasis
- Xuanhong Jin
- , Yang Pan
- & Hongming Pan
-
Article
| Open Access
Development of a CD8+ T cell associated signature for predicting the prognosis and immunological characteristics of gastric cancer by integrating single-cell and bulk RNA-sequencing
- Jianxin Li
- , Ting Han
- & Qingqiang Yang
-
Article
| Open Access
Novel molecular hepatocellular carcinoma subtypes and RiskScore utilizing apoptosis-related genes
- Menggang Zhang
- , Shuijun Zhang
- & Yuting He
-
Article
| Open Access
The Temozolomide–Doxorubicin paradox in Glioblastoma in vitro–in silico preclinical drug-screening
- Mariam-Eleni Oraiopoulou
- , Eleftheria Tzamali
- & Vangelis Sakkalis
-
Article
| Open Access
A dynamic visualization clinical tool constructed and validated based on the SEER database for screening the optimal surgical candidates for bone metastasis in primary kidney cancer
- Liming Jiang
- , Yuexin Tong
- & Dongxu Zhao
-
Article
| Open Access
Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy
- Hengkai Chen
- , Honghao Ye
- & Jinfu Zhuang
-
Article
| Open Access
Rapid prototyping of PMMA-based microfluidic spheroid-on-a-chip models using micromilling and vapour-assisted thermal bonding
- Monieb A. M. Ahmed
- , Klaudia M. Jurczak
- & Anika Nagelkerke
-
Article
| Open Access
In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- Shaimaa E. Diab
- , Nourhan A. Tayea
- & Zakia A. Olama
-
Article
| Open Access
Survival prediction of glioblastoma patients using modern deep learning and machine learning techniques
- Samin Babaei Rikan
- , Amir Sorayaie Azar
- & Uffe Kock Wiil
-
Article
| Open Access
A home-based lifestyle intervention program reduces the tumorigenic potential of triple-negative breast cancer cells
- Giulia Baldelli
- , Valentina Natalucci
- & Mauro De Santi
-
Article
| Open Access
GlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning
- Shuhua Zheng
- , Nikhil Rammohan
- & Tarita O. Thomas
-
Article
| Open Access
A new (T-X\(^\theta\)) family of distributions: properties, discretization and estimation with applications
- Rasha M. Mandouh
- , Mahmoud R. Mahmoud
- & Rasha E. Abdelatty
-
Editorial
| Open AccessAdvancing cancer immunotherapy: from innovative preclinical models to clinical insights
The rapid expansion of cancer immunology and immunotherapy builds upon the success of early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T cells for some cancer types. Many gaps still exist, however, in the scientific knowledge of immune dysfunction in the tumour microenvironment and predicting clinical immunotherapy response to allow more cancer patients to benefit from immunotherapy. The Cancer Immunotherapy Collection within Scientific Reports describes pioneering preclinical and clinical studies addressing these concepts, representing significant insights and breakthroughs in the field.
- Andrew W. Craig
- , Hermann B. Frieboes
- & Paula A. Videira
-
Article
| Open Access
Immune, metabolic landscapes of prognostic signatures for lung adenocarcinoma based on a novel deep learning framework
- Shimei Qin
- , Shibin Sun
- & Lina Chen
-
Article
| Open Access
Characterization of dabrafenib-induced drug insensitivity via cellular barcoding and collateral sensitivity to second-line therapeutics
- Rana Can Baygin
- , Kubra Celikbas Yilmaz
- & Ahmet Acar
-
Article
| Open Access
Whole‑exome sequencing reveals Lewis lung carcinoma is a hypermutated Kras/Nras–mutant cancer with extensive regional mutation clusters in its genome
- Quan He
- , Cuirong Sun
- & Yuanjiang Pan
-
Article
| Open Access
Prognostic value of normal levels of preoperative tumor markers in colorectal cancer
- Guangming Ren
- , Ruikai Li
- & Fan Feng
-
Article
| Open Access
Mathematical model predicts tumor control patterns induced by fast and slow cytotoxic T lymphocyte killing mechanisms
- Yixuan Wang
- , Daniel R Bergman
- & Trachette L. Jackson
-
Article
| Open Access
Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion
- Olga Meiri Chaim
- , Shunichiro Miki
- & Joan Heller Brown
-
Article
| Open Access
SIRT6 promotes metastasis and relapse in HER2-positive breast cancer
- Cristina Andreani
- , Caterina Bartolacci
- & Augusto Amici
-
Article
| Open Access
Identification and validation of telomerase related lncRNAs signature to predict prognosis and tumor immunotherapy response in bladder cancer
- Xiaoxu Chen
- , Zheng Qin
- & Haitao Wang
-
Article
| Open Access
Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression
- Yikai Wang
- , Muqi Wang
- & Shuangsuo Dang
-
Article
| Open Access
A deep learning model predicts the presence of diverse cancer types using circulating tumor cells
- Somayah Albaradei
- , Nofe Alganmi
- & Xin Gao
-
Article
| Open Access
Identification and validation of candidate clinical signatures of apolipoprotein L isoforms in hepatocellular carcinoma
- Xiang-Kun Wang
- , Yu-Xiang Guo
- & Ren-Feng Li
-
Article
| Open Access
A new model to estimate duration of survival in patients with hepatocellular carcinoma with BCLC intermediate stage
- Masashi Ninomiya
- , Mio Tsuruoka
- & Atsushi Masamune
-
Article
| Open Access
Leveraging diverse cell-death patterns to predict the prognosis, immunotherapy and drug sensitivity of clear cell renal cell carcinoma
- Xi Zhang
- , Mingcong Zhang
- & Ninghong Song
-
Article
| Open Access
Construction of an anoikis-associated lncRNA-miRNA-mRNA network reveals the prognostic role of β-elemene in non-small cell lung cancer
- Kai Tan
- , Changhui Zhang
- & Puhua Zeng
-
Article
| Open Access
Tumor microenvironment heterogeneity in bladder cancer identifies biologically distinct subtypes predicting prognosis and anti-PD-L1 responses
- YaFei Li
- , Yi Liu
- & Nan Liu
-
Article
| Open Access
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness
- J. Arévalo
- , I. Campoy
- & A. Meseguer
-
Article
| Open Access
Machine learning-based prediction models for parathyroid carcinoma using pre-surgery cognitive function and clinical features
- Yuting Wang
- , Bojun Wei
- & Dalin Feng
-
Article
| Open Access
Evaluation of cell surface vimentin positive circulating tumor cells as a prognostic biomarker for stage III/IV colorectal cancer
- Jiazi Yu
- , Mian Yang
- & Yuepeng Cao
-
Article
| Open Access
Diet-induced rewiring of the Wnt gene regulatory network connects aberrant splicing to fatty liver and liver cancer in DIAMOND mice
- Ana López-Pérez
- , Silvia Remeseiro
- & Andreas Hörnblad
Variable characteristics overlooked in human K-562 leukemia cell lines with a common signature