Cancer imaging articles within Nature Chemistry

Featured

  • Article |

    The design and construction of a stereo-defined DNA-encoded chemical library, featuring the four different 4-amino-proline stereoisomers as a central scaffold, has now enabled the discovery of potent ligands to proteins of pharmaceutical interest. Parallel screening with closely related isoforms (anti-targets) facilitated the isolation of hits with high selectivity ratios.

    • Sebastian Oehler
    • , Laura Lucaroni
    •  & Gabriele Bassi

  • Article |

    Water-soluble, cell-permeable, inert fluorescent tags called OregonFluors have been developed to withstand environmental changes while resistant towards non-specific binding with subcellular structures. These tags enable quantitative imaging of drug target availability in cells and tissues, providing a route for the future assessment of personalized therapies.

    • Lei G. Wang
    • , Antonio R. Montaño
    •  & Summer L. Gibbs

  • Article |

    Imaging-based companion diagnostics can provide real-time information to match therapies to patients; however, glutathione is abundant in most cells, making it an unlikely candidate for companion diagnosis. Now, a chemical probe has been developed that can detect elevated glutathione concentrations via photoacoustic imaging. Using this probe enables normal and pathological states in a lung cancer model to be distinguished.

    • Melissa Y. Lucero
    •  & Jefferson Chan

  • Research Highlights |

    Contrast agents for highly sensitive imaging applications can be rapidly delivered to tumours by assembling them with nanoparticles at the tumour site.

    • Anne Pichon

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