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Open Access
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| Open AccessPhotosynthetically-powered phototactic active nematic liquid crystal fluids and gels
Cyanobacteria convert light and energy into physical movement. Here, the effect of light intensity gradients on the motion of dense bacterial filaments is investigated, revealing self-assembly of 2D and 3D active nematic states, and changes in orientational and velocity order parameters.
- Andrii Repula
- , Colin Gates
- & Ivan I. Smalyukh
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Article
| Open AccessDurable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices
Poor material biocompatibility of implanted medical devices endangers patient safety and impairs device functionality. Here, durable zwitterion grafts attached onto polymeric surfaces via plasma functionalization lead to superhydrophilic materials for safer and more durable devices.
- Matthew Crago
- , Richard Tan
- & Sina Naficy
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Article
| Open AccessBarnacle cement protein as an efficient bioinspired corrosion inhibitor
Metallic surfaces are often coated with corrosion inhibitors to prevent damage but these are typically toxic to the environment. Here, a recombinant adhesive cement protein from barnacles is shown to effectively protect steel against corrosion under marine environment conditions.
- My Hanh Bui
- , Shu Hui Hiew
- & Ali Miserez
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Article
| Open AccessMyosin-independent stiffness sensing by fibroblasts is regulated by the viscoelasticity of flowing actin
Extracellular matrix stiffness induces differential tension within integrinbased adhesions but it is not known if this is solely from myosin activity. Here, it is shown that 3T3 fibroblasts still transmit stiffness-dependent traction even with the absence of myosin contractility.
- Nikhil Mittal
- , Etienne B. Michels
- & Sangyoon J. Han
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Review Article
| Open AccessPlasmonics for neuroengineering
Plasmonic nanomaterials, such as nanoparticles, efficiently deliver light to target cells for neuromodulation that is less invasive and has higher spatial resolution than common electrical methods. This review covers recent developments in the use of plasmonics for neuroengineering.
- N. S. Susan Mousavi
- , Khalil B. Ramadi
- & Sunil Kumar
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Perspective
| Open AccessChallenges and opportunities for innovation in bioinformed sustainable materials
The design and manufacture of materials that replicate the form, function, and sustainability of biological solutions remains difficult. Here, key challenges and promising approaches to materials development informed by biology are identified.
- Devi Stuart-Fox
- , Leslie Ng
- & Wallace W. H. Wong
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Article
| Open AccessA catch bond mechanism with looped adhesive tethers for self-strengthening materials
Catch bonds exist in some protein-ligand complexes and are of interest for their increased lifetime under greater mechanical force. Here, a mathematical model for nanoparticles tethered with macromolecules shows catch-bond behavior, which may be useful for designing synthetic materials.
- Kerim C. Dansuk
- , Subhadeep Pal
- & Sinan Keten
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Article
| Open AccessImpact of physio-chemical spinning conditions on the mechanical properties of biomimetic spider silk fibers
The mechanical properties of spider silk are known to be dependent on spinning conditions. Here, the tensile behavior of over 1000 biomimetic spider silk fibers spun under 92 different conditions are tested, resulting in a yield strength of more than 250 MPa.
- Benjamin Schmuck
- , Gabriele Greco
- & Anna Rising
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Article
| Open AccessExtracellular matrix-inspired hydrogel of hyaluronan and gelatin crosslinked via a Link module with a transglutaminase reactive sequence
Hydrogels are promising for tissue engineering, in particular for replacing the extracellular matrix. Here, an extracellular matrix inspired hydrogel is created from hyaluronan and gelatin, which cell culture and animal experiments shows to be biocompatible and biodegradable.
- Masashi Okawa
- , Aki Tanabe
- & Taichi Ito
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Article
| Open AccessLiquid-solid contact electrification when water droplets hit living plant leaves
Contact electrification can generate useable charge on a variety of surfaces. Here, surface charge creation when a single water droplet hits various plant leaves is investigated, including the effect of droplet characteristics and whether the plant leaf is hydrophilic or hydrophobic.
- Serena Armiento
- , Carlo Filippeschi
- & Barbara Mazzolai
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Article
| Open AccessEnzymatic upgrading of nanochitin using an ancient lytic polysaccharide monooxygenase
Enzymes are effective at chemically converting low-value biomass to technological materials. Here, an ancestral lytic polysaccharide monooxygenase enzyme is used to synthesize chitin nanocrystals, which are used as a matrix for cell growth and to create conducting graphene oxide bioinks.
- Leire Barandiaran
- , Borja Alonso-Lerma
- & Raul Perez-Jimenez
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Article
| Open AccessBioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles
Textiles that block the transmission of viral particles help to reduce virus spread. Here, peptides on the surface a bioengineered textile capture SARS-CoV-2 viral particles, reducing onward infection by 500-fold.
- Laura Navone
- , Kaylee Moffitt
- & Robert E. Speight
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Article
| Open AccessIn vivo engraftment into the cornea endothelium using extracellular matrix shrink-wrapped cells
Tissue regeneration by injecting cells into the damaged area is a common clinical treatment, but is not always affective. Here, a shrink-wrap-like process is reported for corneal endothelial cells, allowing them to be engrafted into the corneal endothelium of a rabbit animal model.
- Rachelle N. Palchesko
- , Yiqin Du
- & Adam W. Feinberg
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Article
| Open AccessIdentifying chemically similar multiphase nanoprecipitates in compositionally complex non-equilibrium oxides via machine learning
Characterizing fission products in uranium dioxide nuclear fuel is important for predicting its long-term properties. Here, machine learning is used to mine microscopy images of precipitates and nanoscale gas bubbles in high-burn-up fuels, providing detailed structural insight of nanoscale fission products.
- Keyou S. Mao
- , Tyler J. Gerczak
- & Philip D. Edmondson
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Article
| Open AccessSensitizer-enhanced two-photon patterning of biomolecules in photoinstructive hydrogels
Proteins can be patterned in photoresponsive hydrogels by the application of light. Here, a two-photon lithography-based approach allows for the 3D patterning of proteins with micrometer precision, demonstrated for a photoinstructive hydrogel and relevant to a range of proteins.
- Heike Krüger
- , Marvin Asido
- & Ralph Wieneke
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Article
| Open AccessProgrammable polymorphism of a virus-like particle
Virus-like particles are promising for drug delivery systems and vaccine development, but controlling their size and morphology is challenging. Here, amino acid sequences are inserted into MS2 bacteriophage virus-like particles, with their size and shape being controlled by varying the insert used.
- Artur P. Biela
- , Antonina Naskalska
- & Jonathan G. Heddle
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| Open AccessFast and real-time electrical transistor assay for quantifying SARS-CoV-2 neutralizing antibodies
The COVID-19 pandemic highlights the importance of tests for assessing antibody titer, such as for determining vaccine efficacy. Here, a fast-operating organic electrochemical transistor is shown to assess the cytopathic effect caused by the SARS CoV-2 virus on Vero E6 cells in real-time.
- Francesco Decataldo
- , Laura Grumiro
- & Vittorio Sambri
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Article
| Open AccessCreation of stable water-free antibody based protein liquids
Antibodies are widely used in biotechnology and bioengineering, but are sensitive to their environment. Here, primary antibodies are converted into thermally-stable protein liquids, achieving >60% antigen binding after cyclic heating at 125 °C and remain active when incorporated into plastics.
- Joseph M. Slocik
- , Patrick B. Dennis
- & Rajesh R. Naik
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Perspective
| Open AccessOrganic semiconductors for light-mediated neuromodulation
There is growing interest in organic semiconductor devices for light-mediated neuromodulation, such as for retinal stimulation. Here, the key working principles of these devices are discussed, as well as promising applications and outstanding challenges for the field.
- Danashi Imani Medagoda
- & Diego Ghezzi
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Article
| Open AccessPlant-like hooked miniature machines for on-leaf sensing and delivery
Miniaturized systems for in situ plant applications are important to understand and preserve natural ecosystems. Here, the attachment of bioinspired microhooks to the surfaces of plant leaves is investigated, and on-leaf soft machines fabricated for monitoring conditions and for molecular delivery.
- Isabella Fiorello
- , Fabian Meder
- & Barbara Mazzolai
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Article
| Open AccessA transparent waveguide chip for versatile total internal reflection fluorescence-based microscopy and nanoscopy
Total internal reflection fluorescence microscopy typically relies on opaque optical waveguides, compatible only with upright microscopes. Here, a versatile approach is reported that uses CMOS-compatible transparent chips, demonstrated for the imaging of synthetic and biological samples, including super-resolution applications.
- Anish Priyadarshi
- , Firehun Tsige Dullo
- & Ganapathy Senthil Murugan
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Article
| Open AccessIn situ plant materials hyperspectral imaging by multimodal scattering near-field optical microscopy
Plant cells are elaborate three-dimensional polymer nano-constructs with complex chemistry. Here, multimodal scattering nearfield optical microscopy of poplar trees is used to establish in situ high-resolution mappings of the local dielectric functions and compositional distribution of lignin and cellulose in plant cell walls.
- Anne M. Charrier
- , Aubin C. Normand
- & Aude L. Lereu
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Review Article
| Open AccessAntiviral surfaces and coatings and their mechanisms of action
The COVID-19 pandemic has highlighted the importance of materials and coatings for antiviral surfaces. Here, a comprehensive review is performed for natural and synthetic antiviral and virucidal materials, including a discussion of their underpinning mechanisms.
- Paulina D. Rakowska
- , Mariavitalia Tiddia
- & Ian S. Gilmore
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Article
| Open AccessTyrosine residues mediate supercontraction in biomimetic spider silk
Exposing spider silk to wet conditions can cause supercontraction. Here, tyrosine amino acid residues within the amorphous regions are found to contribute to supercontraction, which can be controlled by protein engineering.
- Gabriele Greco
- , Tina Arndt
- & Anna Rising
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Article
| Open AccessPhotovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas
A major challenge artificial retinas face is being able to activate neurons across a wide visual field. Here, a photovoltaic epiretinal prosthetic with over 10,000 pixels shows wide retinal coverage and single-pixel illumination, offering high spatial resolution discrimination in mouse models.
- Naïg Aurelia Ludmilla Chenais
- , Marta Jole Ildelfonsa Airaghi Leccardi
- & Diego Ghezzi
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Article
| Open AccessMicrostructural degradation during the storage of biomass pellets
Biomass pellets are a promising renewable source of fuel, and are increasingly transported around the globe. Here, it is found that the combined effect of heat and humidity during pellet storage causes inclusion, pore and crack growth, degrading the microstructure.
- Luis Cutz
- , Urša Tiringer
- & Wiebren de Jong
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Article
| Open AccessSoil microbiomes mediate degradation of vinyl ester-based polymer composites
The effect of microbial communities on the degradation of polymer composites has not been widely studied. Here, a multi-omics and materials characterization approach reveals the time-dependent effect of naturally occurring microbes on the degradation of vinyl ester composites.
- Adam M. Breister
- , Muhammad A. Imam
- & Pavana Prabhakar
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Article
| Open AccessThe role of valve stiffness in the insurgence of deep vein thrombosis
Deep vein thrombosis is the clotting of blood in deep veins. Here, a microfluidic device containing flexible valves fabricated in-situ is used to investigate the effects of blood flow conditions and valve elasticity on thrombus formation, revealing the circumstance under which clotting occurs.
- Zoe Schofield
- , Hosam Alden Baksamawi
- & Daniele Vigolo
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Article
| Open AccessHigh performance crystalline nanocellulose using an ancestral endoglucanase
Enzymes are effective at upgrading natural materials to high-performance biomaterials. Here, an ancestral endoglucanase is used to obtain highly crystalline cellulose nanocrystals, which can act as a matrix for cell growth and be combined with graphene for conducting inks.
- Borja Alonso-Lerma
- , Leire Barandiaran
- & Raul Perez-Jimenez
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Article
| Open AccessDesigning bioinspired brick-and-mortar composites using machine learning and statistical learning
Brick-and-mortar composite structures found in nature are known for their superior mechanical performance. Here, computational approaches are used to understand the key design features that control mechanical behavior, providing guidance for the design of improved composites.
- Seyedreza Morsali
- , Dong Qian
- & Majid Minary-Jolandan
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