Biological models articles within Nature Materials

Featured

  • News & Views |

    A bioengineered model incorporating a synthetic extracellular matrix recapitulates the lymphoid tumour microenvironment, making it a valuable tool for drug testing and designing personalized therapies.

    • Akhilesh K. Gaharwar
    •  & Irtisha Singh

  • Article |

    The influence of stress relaxation of the extracellular matrix on the formation of intestinal organoids was investigated. It was shown that a stress-relaxing synthetic matrix promotes crypt budding through increased symmetry breaking and niche cell formation.

    • Antonius Chrisnandy
    • , Delphine Blondel
    •  & Matthias P. Lutolf

  • Editorial |

    Over the last few years, there has been a shift towards the use of three-dimensional multicellular structures that more closely recapitulate native tissues and organs as tools to understand development, physiology and pathology.

  • News & Views |

    An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating extracellular matrix deposition and remodelling in a synthetic hydrogel platform.

    • Bauer L. LeSavage
    •  & Sarah C. Heilshorn

  • News & Views |

    Automated extrusion-based bioprinting has been shown to enable human kidney organoid generation with improved throughput, quality control and scale, representing an important step towards macro-scale kidney tissue engineering.

    • Benjamin D. Humphreys

  • News & Views |

    A bioprinting approach that utilizes organoid-forming stem cells as a living ink within hydrogels guides tissue-scale self-organization to generate more realistic gastrointestinal and vascular tissue constructs.

    • Zev J. Gartner
    •  & Jennifer L. Hu

  • News & Views |

    Mutations in lamins in skeletal muscle cells have been shown to reduce nuclear stability, increase nuclear envelope rupture, and induce DNA damage and cell death. New research shows that limiting mechanical loads can rescue myofibre function and viability.

    • Joel C. Eissenberg
    •  & Susana Gonzalo

  • Article |

    Lamin mutations responsible for muscular dystrophy are shown to reduce nuclear envelope stability, resulting in mechanically induced nuclear envelope rupture, DNA damage and activation of DNA damage response pathways that lead to muscle cell death. Preventing nuclear envelope damage by reducing cytoskeletal forces on the nucleus improves muscle fibre health and function.

    • Ashley J. Earle
    • , Tyler J. Kirby
    •  & Jan Lammerding

  • News & Views |

    Blocking the growth of new blood vessels has been shown to alter fibrosis in livers in a disease stage-specific manner. In vitro models of fibrosis were developed to understand this process, highlighting the role of environmental mechanics.

    • Geoffrey C. Gurtner
    •  & Jagannath Padmanabhan

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