Animal disease models articles within Nature Materials

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• Review Article | 17 August 2020

  Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

  This Review highlights approaches used to generate somatic cell-derived organoids for modelling epithelial tissue to understand disease progression and how they are employed in preclinical drug screening.

  • Masayuki Fujii
  •  & Toshiro Sato

• News & Views | 24 March 2020

  Pushing the limit on laminopathies

  Mutations in lamins in skeletal muscle cells have been shown to reduce nuclear stability, increase nuclear envelope rupture, and induce DNA damage and cell death. New research shows that limiting mechanical loads can rescue myofibre function and viability.

  • Joel C. Eissenberg
  •  & Susana Gonzalo