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| Open AccessElevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma
- Xun Li
- , Cheng-Cheng Zhang
- & Chuan-Ming Xie
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Article
| Open AccessLactate exacerbates lung damage induced by nanomicroplastic through the gut microbiota–HIF1a/PTBP1 pathway
- Lihui Xuan
- , Zheng Xu
- & Ruixue Huang
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Review Article
| Open AccessA stepwise activation model for the insulin receptor
- Na-Oh Yunn
- , Junhong Kim
- & Yunje Cho
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Review Article
| Open AccessPhosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
- Eun-Young Lee
- , Jungwon Hwang
- & Myung Hee Kim
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Review Article
| Open AccessLipocalin-2: a therapeutic target to overcome neurodegenerative diseases by regulating reactive astrogliosis
- Byung-Kwon Jung
- & Kwon-Yul Ryu
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Article
| Open AccessLactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
- Yong Jin An
- , Sihyang Jo
- & Sunghyouk Park
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Article
| Open AccessStructure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser
- Hoyoung Kim
- , Taehyun Lim
- & Hyun-Soo Cho
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Article
| Open AccessElevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice
- Jie Zhang
- , Xiao-Tong Lin
- & Chuan-Ming Xie
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Article
| Open AccessDysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder
- Gaeun Park
- , Wooyoung Eric Jang
- & Yong-Seok Lee
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Article
| Open AccessWg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model
- Jung-Eun Park
- , Jiyoun Lee
- & Min-Ji Kang
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Article
| Open AccessAblation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
- Jung-Hwan Baek
- , Myung Sup Kim
- & Kyung-Hee Chun
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Article
| Open AccessCrystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation
- Jimin Yang
- , Guo Nan Yin
- & Ho Min Kim
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Review Article
| Open AccessBiological roles of the RNA m6A modification and its implications in cancer
- Juyeong Hong
- , Kexin Xu
- & Ji Hoon Lee
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Review Article
| Open AccessThe diverse repertoire of ISG15: more intricate than initially thought
- Ji An Kang
- , Yoon Jung Kim
- & Young Joo Jeon
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Review Article
| Open AccessPhase separation of low-complexity domains in cellular function and disease
- Jiwon Lee
- , Hana Cho
- & Ilmin Kwon
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Review Article
| Open AccessMeasurement of lipid flux to advance translational research: evolution of classic methods to the future of precision health
- Amadeo F. Salvador
- , Chi-Ren Shyu
- & Elizabeth J. Parks
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Article
| Open AccessBMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity
- Seung-Hyun Bae
- , Jung-Hoon Kim
- & Hyonchol Jang
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Article
| Open AccessTGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways
- Zhenzhen Zhao
- , Yumeng Zhang
- & Jingfa Zhang
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Article
| Open AccessLatrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
- Guo Nan Yin
- , Do-Kyun Kim
- & Ho Min Kim
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Article
| Open AccessThe optimized core peptide derived from CABIN1 efficiently inhibits calcineurin-mediated T-cell activation
- Sangho Lee
- , Han-Teo Lee
- & Hong-Duk Youn
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Article
| Open AccessUpregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response
- Goon-Tae Kim
- , Shivani Devi
- & Tae-Sik Park
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Article
| Open AccessLipidome profile predictive of disease evolution and activity in rheumatoid arthritis
- Jung Hee Koh
- , Sang Jun Yoon
- & Wan-Uk Kim
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Review Article
| Open AccessO-GlcNAcylation in health and neurodegenerative diseases
- Byeong Eun Lee
- , Pann-Ghill Suh
- & Jae-Ick Kim
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Review Article
| Open AccessConcept and application of circulating proteasomes
- Won Hoon Choi
- , Sumin Kim
- & Min Jae Lee
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Article
| Open AccessREDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression
- Minsik Park
- , Joohwan Kim
- & Young-Myeong Kim
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Article
| Open AccessMelatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
- Quynh Hoa Tran
- , Dang Hieu Hoang
- & Joohun Ha
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Article
| Open AccessSynergistic cycles of protease activity and inflammation via PPARγ degradation in chronic obstructive pulmonary disease
- Nakwon Kwak
- , Kyoung-Hee Lee
- & Chul-Gyu Yoo
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Article
| Open AccessProto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity
- Won-Il Choi
- , Jae-Hyun Yoon
- & Man-Wook Hur
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Article
| Open AccessCereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1
- Hyo Jae Kang
- , Kyung Jin Lee
- & Kyoung-Hee Lee
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Review Article
| Open AccessSlimy partners: the mucus barrier and gut microbiome in ulcerative colitis
- Jian Fang
- , Hui Wang
- & Xiaohong Zhang
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Article
| Open AccessMelatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage
- Goowon Yang
- , Minhyeok Song
- & Joohun Ha
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Review Article
| Open AccessSimilar sequences but dissimilar biological functions of GDF11 and myostatin
- Joonho Suh
- & Yun-Sil Lee
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Review Article
| Open AccessStat2 stability regulation: an intersection between immunity and carcinogenesis
- Cheol-Jung Lee
- , Hyun-Jung An
- & Yong-Yeon Cho
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Review Article
| Open AccessGlutamine reliance in cell metabolism
- Hee Chan Yoo
- , Ya Chun Yu
- & Jung Min Han
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Review Article
| Open AccessSUMO and cellular adaptive mechanisms
- Hong-Yeoul Ryu
- , Seong Hoon Ahn
- & Mark Hochstrasser
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Article
| Open AccessThe cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels
- Abdul Basit
- , Min-Guk Cho
- & Jae-Ho Lee
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Article
| Open AccessQuantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells
- Chih-Ta Chen
- , Li-Zhu Liao
- & Lu-Ping Chow
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Review Article
| Open AccessTherapeutics targeting the fibrinolytic system
- Haili Lin
- , Luning Xu
- & Peng Xu
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Review Article
| Open AccessAssembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond
- Hyun Ji Ha
- , Hye Lin Chun
- & Hyun Ho Park
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Article
| Open AccessUVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes
- Minjung Chae
- , Eui Dong Son
- & Ji-Yong Jung
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Review Article
| Open AccessA short guide to histone deacetylases including recent progress on class II enzymes
- Suk-Youl Park
- & Jeong-Sun Kim
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Review Article
| Open AccessAmino acid transporters as tetraspanin TM4SF5 binding partners
- Jae Woo Jung
- , Ji Eon Kim
- & Jung Weon Lee
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Article
| Open AccessUnleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
- Hye-Kyung Park
- , Nam Gu Yoon
- & Byoung Heon Kang
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Article
| Open AccessHigh levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication
- Zhezhu Han
- , Yeonsoo Joo
- & Jae J. Song
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Article
| Open AccessParticulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
- Yea Seong Ryu
- , Kyoung Ah Kang
- & Jin Won Hyun
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Article
| Open AccessThe flagellin-TLR5-Nox4 axis promotes the migration of smooth muscle cells in atherosclerosis
- Jinoh Kim
- , Jung-Yeon Yoo
- & Yun Soo Bae
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Article
| Open AccessPhosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex
- Sara Hernández-Ortega
- , Abril Sánchez-Botet
- & Josep Clotet
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Article
| Open AccessA PDE1 inhibitor reduces adipogenesis in mice via regulation of lipolysis and adipogenic cell signaling
- Nam-Jun Kim
- , Jung-Hwan Baek
- & Kyung-Hee Chun
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Article
| Open AccessThe role of FGF-2 in smoke-induced emphysema and the therapeutic potential of recombinant FGF-2 in patients with COPD
- You-Sun Kim
- , Goohyeon Hong
- & Young-Koo Jee
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