Alternative splicing articles within Nature Methods

Featured

• Research Highlight | 08 April 2022

  Sequencing RNA isoforms in brain tissue

  Single-nuclei isoform RNA sequencing enables cell-type specific isoform analysis in frozen brain samples.

  • Lei Tang

• Research Highlight | 02 July 2018

  Transcripts from a spliceosome

  Two new methods provide high-resolution profiles of splicing events in yeast.

  • Tal Nawy

• Research Highlights | 27 April 2018

  CRISPR–Cas goes RNA

  CasRx is a programmable CRISPR–Cas system that targets RNA for efficient knockdown and splicing modulation.

  • Stéphane Larochelle

• Tools in Brief | 31 October 2017

  Alternative splice atlas

• Research Highlights | 29 September 2017

  The proof of splicing is in the proteome

  An integrated workflow allows the quantitative interrogation of the impact of alternative splicing at the proteome level.

  • Stéphane Larochelle

• Research Highlights | 30 March 2016

  Protein isoforms: more than meets the eye

  Alternative splicing imparts distinct functions through isoform-specific protein–protein interactions.

  • Stéphane Larochelle

• News & Views | 29 September 2010

  Simplifying complexity

  A software tool based on gene model profiling improves analysis of alternative splice events in RNA sequencing (RNA-seq) data.

  • Nicole Cloonan
  •  & Sean M Grimmond