Adaptive immunity articles within Nature Reviews Endocrinology

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  • Review Article |

    This Review summarizes adaptive immune cell dysregulation in obesity and type 2 diabetes mellitus (T2DM). Under-appreciated comorbidities of obesity and T2DM (oral cavity inflammation, neuroinflammation and dysbiosis) are considered, and previous clinical trials of anti-inflammatory therapies for T2DM are discussed.

    • Sara SantaCruz-Calvo
    • , Leena Bharath
    •  & Barbara S. Nikolajczyk

  • Review Article |

    Advances in understanding of B-lymphocyte maturation and immune tolerance are yielding new insight into the influence of gonadal steroids on the humoral immune system. Kovacs and colleagues examine how oestrogens and androgens directly and indirectly modulate B-lymphocyte development and function, focusing on B lymphopoiesis, elimination of autoreactive B-cell clones, and generation of high-affinity, class-switched, immunoglobulin-producing B cells.

    • Sanaz Sakiani
    • , Nancy J. Olsen
    •  & William J. Kovacs

  • Review Article |

    Obesity is a key feature of the metabolic syndrome and increased adiposity has been associated with inflammation in the visceral compartment. In this Review, the authors describe inflammatory processes that occur in adipose tissue, focussing on how adaptive immune system cells promote inflammation.

    • Henrike Sell
    • , Christiane Habich
    •  & Juergen Eckel

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