Lyme disease

Definition

Lyme disease, formerly known as Lyme arthritis, is an infectious disease transmitted to humans by deer ticks infected with the spirochete Borrelia burgdorferi. The primary infection can spread to secondary sites including the nervous system, heart and musculoskeletal system.

Latest Research and Reviews

  • Reviews |

    Lyme borreliosis is a tick-borne disease that is caused by the bacteria Borrelia burgdorferi, Borrelia afzelii and Borrelia garinii. This Primer by Steere and colleagues discusses the epidemiology, mechanisms and management of Lyme borreliosis in North America and Europe.

    • Allen C. Steere
    • , Franc Strle
    • , Gary P. Wormser
    • , Linden T. Hu
    • , John A. Branda
    • , Joppe W. R. Hovius
    • , Xin Li
    •  & Paul S. Mead
  • Research | | open

    Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularis and uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

    • Monika Gulia-Nuss
    • , Andrew B. Nuss
    • , Jason M. Meyer
    • , Daniel E. Sonenshine
    • , R. Michael Roe
    • , Robert M. Waterhouse
    • , David B. Sattelle
    • , José de la Fuente
    • , Jose M. Ribeiro
    • , Karine Megy
    • , Jyothi Thimmapuram
    • , Jason R. Miller
    • , Brian P. Walenz
    • , Sergey Koren
    • , Jessica B. Hostetler
    • , Mathangi Thiagarajan
    • , Vinita S. Joardar
    • , Linda I. Hannick
    • , Shelby Bidwell
    • , Martin P. Hammond
    • , Sarah Young
    • , Qiandong Zeng
    • , Jenica L. Abrudan
    • , Francisca C. Almeida
    • , Nieves Ayllón
    • , Ketaki Bhide
    • , Brooke W. Bissinger
    • , Elena Bonzon-Kulichenko
    • , Steven D. Buckingham
    • , Daniel R. Caffrey
    • , Melissa J. Caimano
    • , Vincent Croset
    • , Timothy Driscoll
    • , Don Gilbert
    • , Joseph J. Gillespie
    • , Gloria I. Giraldo-Calderón
    • , Jeffrey M. Grabowski
    • , David Jiang
    • , Sayed M. S. Khalil
    • , Donghun Kim
    • , Katherine M. Kocan
    • , Juraj Koči
    • , Richard J. Kuhn
    • , Timothy J. Kurtti
    • , Kristin Lees
    • , Emma G. Lang
    • , Ryan C. Kennedy
    • , Hyeogsun Kwon
    • , Rushika Perera
    • , Yumin Qi
    • , Justin D. Radolf
    • , Joyce M. Sakamoto
    • , Alejandro Sánchez-Gracia
    • , Maiara S. Severo
    • , Neal Silverman
    • , Ladislav Šimo
    • , Marta Tojo
    • , Cristian Tornador
    • , Janice P. Van Zee
    • , Jesús Vázquez
    • , Filipe G. Vieira
    • , Margarita Villar
    • , Adam R. Wespiser
    • , Yunlong Yang
    • , Jiwei Zhu
    • , Peter Arensburger
    • , Patricia V. Pietrantonio
    • , Stephen C. Barker
    • , Renfu Shao
    • , Evgeny M. Zdobnov
    • , Frank Hauser
    • , Cornelis J. P. Grimmelikhuijzen
    • , Yoonseong Park
    • , Julio Rozas
    • , Richard Benton
    • , Joao H. F. Pedra
    • , David R. Nelson
    • , Maria F. Unger
    • , Jose M. C. Tubio
    • , Zhijian Tu
    • , Hugh M. Robertson
    • , Martin Shumway
    • , Granger Sutton
    • , Jennifer R. Wortman
    • , Daniel Lawson
    • , Stephen K. Wikel
    • , Vishvanath M. Nene
    • , Claire M. Fraser
    • , Frank H. Collins
    • , Bruce Birren
    • , Karen E. Nelson
    • , Elisabet Caler
    •  & Catherine A. Hill
  • Reviews |

    Up to 12% of patients with Lyme disease develop neurological symptoms. This syndrome, Lyme neuroborreliosis, can manifest soon after the initial infection or months to years after the event. Koedel and colleagues discuss the diagnosis and treatment of early and late Lyme neuroborreliosis, and review the controversies surrounding post-treatment Lyme disease syndrome and chronic Lyme disease.

    • Uwe Koedel
    • , Volker Fingerle
    •  & Hans-Walter Pfister
  • Reviews |

    The natural history of untreated Lyme arthritis is rarely observed as most cases are successfully treated with antibiotics. This Case Study discusses a patient with Lyme disease who refused antibiotic therapy during the first 4 years of her illness and demonstrates that antibiotic therapy is still likely to be effective, even following a long-term infection with Borrelia burgdorferi.

    • Robert T. Schoen

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