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In today's episode, Dr. Michael Wolfe of the Laboratory for Experimental Alzheimer Drugs at Harvard Medical School and Brigham & Women's Hospital talks to Adam about the biochemistry underlying Alzheimer's disease (AD). AD is a neurodegenerative disease associated with plaques and tangles in the brain formed by two proteins, amyloid β (Aβ) and tau, that damage and eventually destroy brain cells. Wolfe and his lab study the mechanism responsible for producing Aβ, which builds up over time and comes to negatively affect the parts of the brain essential for memory and cognition. As the brain ages, it becomes less able to clear out Aβ; as result, Wolfe asserts that the increase in life expectancy worldwide will lead to an exponential rise in cases of AD. Knowledge of the proteins responsible for the development of AD is leading to novel approaches to treating the disease, some of which have gone into clinical trals. Join Adam as he learns the biochemistry behind this growing disease as well as potential therapies to treating it. [04:34]
