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Ras and Rap proteins are closely related, bind the same effectors and yet have distinct cellular activities. Precise structural analysis helps to explain their biological differences.
The structural and functional properties of nucleic acids may form the basis for carrying out elementary and complex computational operations with biological molecules. A recent meeting on computing with DNA explored the potential of this approach.
The structure of the killer toxin from the yeast Williopsis mrakii (WmKT) corresponds to a so far hypothetical ancestral single-domain form of the βγ-crystallin structure type, although there is neither significant sequence homology nor coincidence of physiological functions.
Estrogenic 17β-hydroxysteroid dehydrogenase may promote tumour growth in some breast carcinomas. The 2.3 Å structure of the human enzyme complexed with 17β-estradiol gives insight into the specificity of substrate binding.
α1-antichymotrypsin and Alzheimer's Aβ1–42 peptide appear to form a complex whose inferred structure suggests possible mechanisms for stimulation of Alzheimer's amyloid fibril formation.
