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Structure of astacin with a transition-state analogue inhibitor

Nature Structural Biology volume 3, pages 671–675 (1996)Cite this article

Abstract

The structure of the zinc peptidase astacin in complex with a phosphinic peptide suggests that a special role is played by the side chain of a zinc-bound tyrosine, which is shifted to form a hydrogen bond to the phosphinyl group—a mimic of the carboxyanion of the transition state.

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Author notes

  1. Frank Grams

    Present address: Boehringer Mannheim GmbH, Chemical Research, Sandhofer Str. 116, D-68305, Mannheim, Germany

Authors and Affiliations

  1. Max-Planck-lnstitut für Biochemie, Abt. Strukturforschung, Am Klopferspitz 18a, D-82152, Planegg-Martinsried, Germany

    Frank Grams & Wolfram Bode

  2. CEA, Departement d'Ingenierie et d'Etudes des Proteines, C.E. Saclay, 91191, Gif Sur Yvette Cedex, France

    Vincent Dive

  3. Department of Organic Chemistry, University of Athens, Panepistimiopolis, Zogratu, Athens, 15771, Greece

    Athanasios Yiotakis & Stamatia Vassiliou

  4. Zoologisches Institut der Universität Heidelberg, Physiologie, Im Neuenheimer Feld 230, D-69120, Heidelberg, Germany

    Irene Yiallouros, Robert Zwilling & Walter Stöcker

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  1. Frank Grams
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  2. Vincent Dive
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  7. Wolfram Bode
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  8. Walter Stöcker
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Grams, F., Dive, V., Yiotakis, A. et al. Structure of astacin with a transition-state analogue inhibitor. Nat Struct Mol Biol 3, 671–675 (1996). https://doi.org/10.1038/nsb0896-671

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