Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

A specific structural interaction of Alzheimer's peptide Aβ1–42 with α1-antichymotrypsin

Nature Structural Biology volume 3, pages 668–671 (1996)Cite this article

α1-antichymotrypsin and Alzheimer's Aβ1–42 peptide appear to form a complex whose inferred structure suggests possible mechanisms for stimulation of Alzheimer's amyloid fibril formation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kirschner, D.A. et al. Proc. Natn. Acad. Sci. USA 84, 6953–6957 (1987).

    Article  CAS  Google Scholar 

  2. Shoji, M. et al. Science 258, 126–129 (1992).

    Article  CAS  PubMed  Google Scholar 

  3. Haass, C. et al. Nature 359, 322–325 (1992).

    Article  CAS  PubMed  Google Scholar 

  4. Seubert, P. et al. Nature 359, 325–327 (1992).

    Article  CAS  PubMed  Google Scholar 

  5. Abraham, C.R., Selkoe, D.J. & Potter, H. Cell 52, 487–501 (1988).

    Article  CAS  PubMed  Google Scholar 

  6. Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E. & Ikeda, K. Brain Res. 541, 163–166 (1991)

    Article  CAS  PubMed  Google Scholar 

  7. Snow, A.D. et al. Am. J. Pathol. 133, 456–463 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Ma, J., Yee, A., Brewer, H.B., Das, S. & Potter, H. Nature 372, 92–94 (1994).

    Article  CAS  PubMed  Google Scholar 

  9. Potter, H., Abraham, C.R. & Dressler, D. In Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies (eds Iqbal, K. et al.) 275–279 (Wiley, New York; 1991).

    Google Scholar 

  10. Fraser, P.E. et al. J. Neurochem. 61, 298–305 (1993).

    Article  CAS  PubMed  Google Scholar 

  11. Eriksson, S., Janciauskiene, S. & Lannfelt, L. Proc. Natn. Acad. Sci. USA 92, 2313–2317 (1995).

    Article  CAS  Google Scholar 

  12. Mast, A.E., Enghild, J.J. & Salvesen, G. Biochemistry 31, 2720–2728 (1992).

    Article  CAS  PubMed  Google Scholar 

  13. Bruch, M., Weiss, V. & Engel, J. J. Biol. Chem. 263, 16626–16630 (1988).

    CAS  PubMed  Google Scholar 

  14. Carrell, R.W., Evans, D.L.L. & Stein, P.E. Nature 353, 575–578 (1991).

    Article  Google Scholar 

  15. Halverson, K.J., Fraser, P.E., Kirschner, D.A. & Lansbury, P.T., Jr. Biochemistry 29, 2639–2644 (1990).

    Article  CAS  PubMed  Google Scholar 

  16. Barrow, C.J., Yasuda, A., Kenny, P.T.M. & Zagorski, M.G. J. Mol. Biol. 225, 1075–1093 (1992).

    Article  CAS  PubMed  Google Scholar 

  17. Burdick, D. et al. J. Biol. Chem. 267, 546–554 (1992).

    CAS  PubMed  Google Scholar 

  18. Jarrett, J.T., Berger, E.P. & Lansbury, P.T., Jr. Biochemistry 32, 4693–4697 (1993).

    Article  CAS  PubMed  Google Scholar 

  19. Brünger, A.T. X-PLOR version 3.0 (1992).

    Google Scholar 

  20. Zagorski, M.G. & Barrow, C.J. Biochemistry 31, 5621–5631 (1992).

    Article  CAS  PubMed  Google Scholar 

  21. Soto, C. & Frangione, B. Neuroscience Letters 186, 115–118 (1995).

    Article  CAS  PubMed  Google Scholar 

  22. Soto, C., Castaño, E.M., Frangione, B. & Inestrosa, N.C. J. Biol. Chem 270, 3063– 3067 (1995).

    Article  CAS  PubMed  Google Scholar 

  23. Stein, P.E. & Carrell, R.W. Nature Struct. Biol. 2, 96–113 (1995).

    Article  CAS  PubMed  Google Scholar 

  24. Jarrett, J.T. & Lansbury, P.T., Jr. Cell 73, 1055–1058 (1993).

    Article  CAS  PubMed  Google Scholar 

  25. Kraulis, P. J. Applied Cryst. 24, 946–950 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University Hospital of Malmö, Lund University, Malmö, 20502, Sweden

    Sabina Janciauskiene

  2. Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University Richmond, Virginia, 23298-0614, USA

    Sten Eriksson & H. Tonie Wright

Authors
  1. Sabina Janciauskiene
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sten Eriksson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Tonie Wright
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Janciauskiene, S., Eriksson, S. & Wright, H. A specific structural interaction of Alzheimer's peptide Aβ1–42 with α1-antichymotrypsin. Nat Struct Mol Biol 3, 668–671 (1996). https://doi.org/10.1038/nsb0896-668

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0896-668

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing