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Volume 14 Issue 3, March 2007

Work by Hurley and colleagues reveals interactions between the ESCRT protein Alix and HIV-1 Gag p6 that are important for HIV-1 budding. The image of a budding peony, the subject of a photograph entitled "Spring Noir", is evocative of the viral budding process. Photograph kindly provided by Elisabeth Feldman (http://www.flickr.com/photos/hurleygurley).pp 194-199

Volume 14 Issue 3

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  • Karni et al. report in this issue that proteins in the SR family, which modify gene function by alternative splicing, are among the many factors that can transform mammalian cells to malignancy. These splicing proteins regulate alternative splicing of many known proto-oncogenes and tumor-suppressor genes, thereby activating them post-transcriptionally to allow cells to escape normal controls on cell growth and proliferation.

    • Anchang Hu
    • Xiang-Dong Fu
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  • Analyses of telomere-binding proteins show structural and functional conservation with subunits of replication protein A, the canonical single-stranded DNA–binding protein. These studies raise intriguing questions about the structure and general role of DNA binding in telomere length homeostasis.

    • Stuart J Haring
    • Marc S Wold
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  • RNA interference (RNAi) is important in directing heterochromatin assembly at centromeres in fission yeast, which is crucial for maintaining a stable genome through mitotic and meiotic divisions. In this issue, Buker et al. describe a new Argonaute siRNA chaperone (ARC) that converts duplex RNA to single-stranded RNA. This is a previously unknown step in the RNAi-directed heterochromatin-formation pathway.

    • Karl Ekwall
    News & Views

  • Recent structural and functional analyses of MthK, a prokaryotic Ca2+-activated K+ channel, suggest that the interplay between cytoplasmic Ca2+ and H+ concentrations determines the oligomeric stability of its associated RCK domain and thus controls activation gating. However, the discovery of a ligand-dependent desensitization process suggests that gating in these channels might be more complicated than originally envisioned.

    • Sudha Chakrapani
    • Eduardo Perozo
    News & Views
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