Karni et al. report in this issue that proteins in the SR family, which modify gene function by alternative splicing, are among the many factors that can transform mammalian cells to malignancy. These splicing proteins regulate alternative splicing of many known proto-oncogenes and tumor-suppressor genes, thereby activating them post-transcriptionally to allow cells to escape normal controls on cell growth and proliferation.
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Hu, A., Fu, XD. Splicing oncogenes. Nat Struct Mol Biol 14, 174–175 (2007). https://doi.org/10.1038/nsmb0307-174
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DOI: https://doi.org/10.1038/nsmb0307-174
