Translational control is known to be important for regulating the meiotic segregation pattern during gametogenesis, but insights into the precise mechanisms involved have been lacking. B-type cyclin CLB3 is a critical determinant of gametogenesis (known as sporulation in yeast), and its presence is restricted to meiosis II through translational repression during meiosis I. To elucidate the mechanism of translational control, Amon and colleagues found the meiosis-specific Ime2 kinase to be responsible for regulating translational activation of CLB3. Interestingly, mRNA deep sequencing and ribosome profiling of synchronized meiotic budding-yeast cell cultures revealed a gene cluster within which patterns of translation were very similar to those of CLB3. Ime2 also governed translation of this cluster, suggesting a common underlying mechanism. The authors hypothesized that Ime2 inhibits the activity of a translational repressor and identified the meiosis-specific RNA-binding protein Rim4 as an Ime2 substrate. Indeed, Rim4 inhibited translation of CLB3 during meiosis I by interacting with the 5′ UTR of CLB3, and in light of previous work, the authors speculated that Rim4 probably regulates translation at the level of initiation. Although Ime2 kinase activity was low during meiosis I, it rose at the onset of meiosis II and induced a decrease in Rim4 protein levels. It is possible that Ime2-dependent phosphorylation of Rim4 targets the protein for degradation, but Ime2 phosphorylation might also affect the RNA-binding affinity of Rim4. Given its central role in gametogenesis, it will be important to gain further insight into how Ime2 expression and activity are regulated. (Genes Dev. 27, 2147–2163, 2013)