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This second Viewpoint on the issue of neonatal circumcision discusses why this practice might not be beneficial. Van Howe refutes claims that circumcision has a protective effect from genital cancer, urinary tract infections and sexually transmitted infections, and highlights the many adverse events that can be experienced following circumcision.
In this Review, Harris and colleagues discuss historical and contemporary approaches to androgen deprivation therapy for patients with prostate cancer. They then focus on mechanisms of castration resistance, and discuss novel targeted therapies for patients with this disease.
Considerable heterogeneity exists in mechanisms of prostate carcinogenesis. In this Review, Patel and Klein discuss the known risk modifiers for prostate cancer, including age, ethnicity, genetic background, infection, inflammation, diet and lifestyle.
This Review by Fletcher and colleagues provides a holistic approach to the evaluation and management of sexual dysfunction in patients with multiple sclerosis. The article incorporates the latest data from the fields of urology, neurology, nursing, social work, and psychology. The authors assert that the best approach includes open communication with patients and multidisciplinary management.
In this Case Study, Morris and Guimaraes present a 28-year-old man with left orchitis and an incidentally discovered right focal testicular mass. The authors suggest that, for a suspicious mass in the setting of contralateral orchitis, serum tumor markers and serial imaging might be preferred to urgent surgical intervention.
This article discusses the case of a 79-year-old woman with a history of chronic back pain and urinary urgency. Spinal imaging showed that she had spinal stenosis, and she was treated with an epidural steroid injection. Her back pain and urinary urgency improved immediately. This case demonstrates the potential for improving overactive bladder symptoms with a minimally invasive epidural steroid injection in patients with spinal stenosis.
