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In this Viewpoint article by Professor Kattan, the author discusses methods for predicting outcomes in patients with prostate cancer, the predictive accuracy of these methods, and why, despite the large number of nomograms already developed, further nomograms are still needed for predicting outcomes in patients with prostate cancer.
Radical cystectomy is the preferred treatment for nonmetastatic muscle-infiltrating bladder cancer, but several researchers have proposed the use of bladder-sparing approaches. In this Review, Pansadoro and Emiliozzi discuss a variety of possible bladder-sparing approaches and the evidence supporting their use.
Many experimental studies have reported that statins, cholesterol-lowering drugs, inhibit the growth of prostate cancer cells. In this Review, Murtola and colleagues look at the current evidence on the use of statins in the prevention of prostate cancer.
The signs and symptoms of testosterone deficiency can be nonspecific, and can vary according to patient age and the presence of comorbid illnesses, thereby making diagnosis of the disorder difficult. In this Review, Tostain and Blanc highlight the problems and solutions in diagnosing testosterone deficiency by looking at the signs and symptoms, diagnostic tests, and epidemiology of the disorder.
The optimum management of patients with low-stage seminoma remains a matter of debate. Here, Resnick et al. detail the case of a 51-year-old man who was diagnosed with bilateral stage I testicular seminoma. The authors discuss the management of bilateral disease, addressing the implications of surgical castration and the possibility of testis-sparing approaches to treatment.
Distinguishing primary bladder adenocarcinoma from metastatic colorectal cancer represents a diagnostic challenge; however, a correct diagnosis can prevent the patient from receiving inappropriate treatment. Here, Izzo et al. use the case of a 71-year-old woman to highlight important issues in the diagnosis of these bladder neoplasms, with particular focus on the role of immunohistochemistry.
