A new modified protocol of collagenase clostridium histolyticum (CCH) treatment for Peyronie's disease comprising only three instead of eight CCH injections was found to be safe and effective in a single-centre setting. In a cohort of men with mean penile curvature of 54° at baseline, 51 of 53 men had a mean improvement of 17.36° (31.4%). Only mild and transient local adverse events were observed.