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The results of a phase IIb study suggest that ianalumab, an anti-BAFF receptor antibody, could have disease-modifying effects in primary Sjögren syndrome.
A new study shows that resident memory T cells that accumulate in the synovium of arthritic joints contribute to site-specific disease flare, and could present a new therapeutic target.
Researchers have found that hypoxia in articular cartilage is associated with expression of DOT1L, which protects against cartilage damage in a mouse model of osteoarthritis.
New research suggests that macrophage migration inhibitory factor (MIF) might contribute to spondyloarthritis (SpA) by enhancing type 3 immunity, and could be a potential therapeutic target.
A new study suggests that DNMT3A mutations associated with clonal haematopoiesis of indeterminate potential are linked to osteoporosis through IL-20-mediated osteoclastogenesis.
Inhibition of the soluble epoxide hydrolase enzyme prevents metabolism of anti-inflammatory epoxyeicosatrienoic acids and reduces pain in a mouse model of osteoarthritis.
Built by and for the research community, the Musculoskeletal Knowledge Portal (MSK-KP) offers researchers a single integrated platform on which to display, access, distill and explore results from large genomic and epigenomic studies to formulate hypotheses and accelerate the development of patient-centered therapeutics for complex, multi-factorial conditions such as osteoarthritis.
A study published in Nature Biomedical Engineering reports a new biomimetic lubricant that can help restore cartilage in rats with post-traumatic osteoarthritis.
Researchers have created therapeutic implants containing cells engineered to release anti-inflammatory biologic drugs in response to changing endogenous inflammatory signals.
New research shows that cartilage engineered from nasal chondrocytes can integrate with osteoarthritic joint tissues in animal models, and provides early evidence of clinical benefits in patients with knee osteoarthritis.