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A calcium-binding peptide derived from fetuin-A inhibited pathological cartilage calcification in an experimental model of osteoarthritis, suggesting therapeutic potential.
Lipid nanoparticles loaded with type II collagen and rapamycin can induce antigen-specific regulatory T cell responses and alleviate disease in a mouse model of osteoarthritis.
New evidence from animal models and human studies suggests that mammalian target of rapamycin has a role in the pathophysiology of Still’s disease and macrophage activation syndrome.
New research reveals that ferritin has an essential role in neutrophil extracellular trap (NET)-mediated inflammation, and suggests that NETs or the ferritin receptor MSR1 could be targeted for the treatment of adult-onset Still disease.