Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In a rigorous randomized controlled trial, treatment with platelet-rich plasma did not improve knee osteoarthritis symptoms or slow disease progression.
Results of a case–control study suggest that delayed hypersensitivity reactions to IL-1 or IL-6 inhibitors are strongly associated with a common HLA class II haplotype.