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New research shows that annexin A1 has a protective role in periprosthetic osteolysis and could offer a therapeutic approach to this common cause of arthroplasty failure.
New research shows that one of the two main isoforms of the human FOXP3 transcription factor is associated with inflammatory transcriptional regulation and autoimmunity.
New results have identified a targetable pathway involved in invasiveness and resistance to detachment-mediated apoptosis in rheumatoid arthritis synovial fibroblasts.
By isolating CD4+ T cells from patients with primary Sjögren syndrome, a new study has identified the involvement of a targetable interferon signalling pathway in T cell differentiation and B cell activation.
Transcriptomic analysis of synovial tissue from patients with rheumatoid arthritis and psoriatic arthritis reveals new details of the role of immune cell–stromal cell interactions in synovial inflammation.
Individuals with chronic diseases that require constant medical support are particularly vulnerable during wartime and often remain so after the last shot has been fired. What consequences might the Russia–Ukraine war bring for rheumatology?
Results from the R4RA clinical trial indicate that gene signatures in pre-treatment biopsy-derived synovial tissue can predict the response to biologic DMARDs in patients with rheumatoid arthritis.
New research has identified a novel, de novo mutation in the TLR7 gene that increases the affinity of TLR7 for guanosine, leading to TLR7 overactivation and child-onset systemic lupus erthematosus.
A detailed examination of skin cytology in cutaneous lupus erythematosus has identified cellular interactions and an inflammatory environment that exist prior to lesion formation.
New research demonstrates that a hydrogel-based miRNA delivery system might have therapeutic potential to treat osteoarthritis by targeting chondrocyte senescence.
New research demonstrates that the amino acid composition of the hypervariable CDR3 region of T cell receptors is influenced by the presence of HLA risk alleles for autoimmune disease.
A machine learning approach has been used to identify three distinct osteoarthritis endotypes based on biochemical markers related to joint tissue processes.