FIGURE 3 | A schematic showing the simplified pathophysiologic pathways in rheumatoid arthritis and indicating where some of the new approaches currently being investigated might interfere with these processes.

From the following article:

Treatment of rheumatoid arthritis: state of the art 2009

Ronald F. van Vollenhoven

Nature Reviews Rheumatology 5, 531-541 (October 2009)

doi:10.1038/nrrheum.2009.182

Treatment of rheumatoid arthritis: state of the art 2009

Abbreviations: ACPA, anti-citrullinated protein/peptide antibodies; APC, antigen presenting cell; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; RF, rheumatoid factor; TNF, tumor necrosis factor; TREG, regulatory T cell.

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