Volume 14 Issue 1, January 2018

Whether TNF inhibitors prevent structural damage in ankylosing spondylitis remains a controversial topic, as three prospective trials failed to show any evidence to support this notion. However, data are accumulating from retrospective analyses of well-characterized cohorts of patients that could provide the solution to this controversy.

Primary immunodeficiency syndromes and autoimmune diseases seem to be different, but the clinical symptoms can be very similar. In this Review, the authors examine the causes and pathogenesis of several primary immunodeficiency syndromes and highlight their relationship to rheumatic diseases.

This Review discusses the various functions of immunoregulatory semaphorins (known as immune semaphorins) and the role of these proteins in the pathogenesis of autoimmune rheumatic diseases, as well as their potential as diagnostic markers and therapeutic targets.

The symptomatic pre-arthritis phase of rheumatoid arthritis (RA) is hypothesized to be part of a 'window of opportunity' for preventive treatment. This Review discusses the methodological considerations when designing and interpreting preventive trials, and translating findings into clinical practice.

Connexins, hemichannels and gap junctions fulfil important functions in cell–cell communication. In this Review, the authors discuss the role of connexins, hemichannels and gap junctions in musculoskeletal tissues and rheumatic diseases.

Large partnerships between academia and industry are emerging as a possible solution to the problems surrounding stratified medicine. In this Perspectives article, the members of the RA-MAP Consortium reflect on the challenges and benefits of working in such a partnership.