The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

Image supplied by Dr Michal Dudek from the Faculty of Life Sciences, University of Manchester, Manchester, UK. The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

Image supplied by Dr Michal Dudek from the Faculty of Life Sciences, University of Manchester, Manchester, UK. The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

Image supplied by Dr Michal Dudek from the Faculty of Life Sciences, University of Manchester, Manchester, UK. The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

Image supplied by Dr Michal Dudek from the Faculty of Life Sciences, University of Manchester, Manchester, UK. The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.

Image supplied by Dr Michal Dudek from the Faculty of Life Sciences, University of Manchester, Manchester, UK. The image shows knee articular cartilage from a chondrocyte-specific Bmal1-knockout mouse. The tissue was stained with safranin O and fast green. Deletion of the transcription factor brain and muscle Arnt-like protein 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like protein 1), a core component of the circadian clock, results in the loss of circadian rhythm and leads to degeneration of knee cartilage. The circadian clock controls the rhythmic expression of several hundred genes in cartilage and its function can be affected by inflammation and ageing, both of which are risk factors for osteoarthritis. Studies of the circadian clock will help us better understand cartilage physiology in health and disease.