Among 168 patients who were determined to have axial spondyloarthritis (axSpA) according to the clinical arm of the ASAS classification criteria, response to TNF inhibitor therapy was dependent on the presence or absence of objective signs of axSpA (such as arthritis, dactylitis, enthesitis, uveitis and others). Only 13.7% of patients with non-radiographic SpA and no objective signs achieved a 50% improvement in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI 50) at 3 months, compared with 45.1% of the group of patients with one or more objective signs.
References
Vidal, C. et al. Poor efficacy of TNF inhibitors in non-radiographic axial spondyloarthritis in the absence of objective signs: a bicentric retrospective study. Joint Bone Spine http://dx.doi.org/10.1016/j.jbspin.2017.08.005 (2017)
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Onuora, S. Predictive factors of anti-TNF efficacy. Nat Rev Rheumatol 13, 632 (2017). https://doi.org/10.1038/nrrheum.2017.169
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DOI: https://doi.org/10.1038/nrrheum.2017.169
