Volume 13 Issue 5, May 2017

A growing body of evidence indicates that people with migraine have an increased risk of cervical artery dissection (CeAD). A new study in young patients with ischaemic stroke has identified a specific link between CeAD and migraine without aura.

A new survey of clinicians from 21 different countries has found a lack of consensus regarding the definition of familial amyotrophic lateral sclerosis. In addition, attitudes towards genetic testing vary greatly between practitioners. These attitudes must be changed if future therapeutic strategies are to succeed.

Human induced pluripotent stem cells (hiPSCs) enable researchers to recapitulate an individual's neural development in a dish, with the potential to provide unique insight into the pathogenic mechanisms of neurodevelopmental disorders. Here, the authors provide an overview of disease modelling with hiPSCs and discuss existing hiPSC models of neurodevelopmental disorders.

MRI has become the standard method for diagnosis and monitoring of patients with brain tumours, but conventional MRI sequences have important limitations. This Review summarizes the clinical role of the rapidly developing field of amino acid PET and advanced MRI techniques in adults with brain tumours, and provides an outlook for future developments in PET and MRI.

Clinical recognition of autoimmune encephalitis is vital in order for effective early treatment to be provided. Here, van Sonderen and colleagues describe the syndromes associated with antibodies against LGI1, Caspr2 and voltage-gated potassium channels and highlight the importance of determining the molecular identity of patient antibodies for diagnosis and treatment.

Nonsystemic vasculitic neuropathy (NSVN) is an under-recognized single-organ vasculitis of peripheral nerves. In this Review, Collins and Hadden provide an update on the classification, diagnosis and treatment of NSVN, and propose definitions and an up-to-date differential diagnosis of multifocal neuropathy.