In a new study, one-quarter of individuals with a clinical diagnosis of mild to moderate Alzheimer dementia had no or only sparse neuritic amyloid plaques in their brains, and most were also at a low or an intermediate neurofibrillary tangle stage. The findings have enormous implications for clinical trials of anti-amyloid-β and anti-tau therapies.
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Serrano-Pozo, A., Hyman, B. Alzheimer dementia with sparse amyloid—AD mimic or variant?. Nat Rev Neurol 11, 674–675 (2015). https://doi.org/10.1038/nrneurol.2015.221
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DOI: https://doi.org/10.1038/nrneurol.2015.221
