A new study describes a biomarker profile based on cerebrospinal fluid (CSF) tau and amyloid-β1–42 in a uniquely large population with a variety of dementia diagnoses. This study confirms the differential diagnostic value of CSF biomarkers and further highlights the important neuropathological overlap between dementia aetiologies.
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References
Skillbäck, T. et al. Cerebrospinal fluid tau and amyloid-β1–42 in patients with dementia. Brain http://dx.doi.org/10.1093/brain/awv181.
Blennow, K. et al. Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease. Alzheimers Dement. 11, 58–69 (2015).
[No authors listed] Consensus report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer's Disease”. The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobiol. Aging 19, 109–116 (1998).
Jack, C. R. Jr et al. Introduction to the recommendations from the National Institute on Aging–-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7, 257–262 (2011).
De Meyer, G. et al. Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch. Neurol. 67, 949–956 (2010).
Bateman, R. J. et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367, 795–804 (2012).
Dubois, B. et al. Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol. 9, 1118–1127 (2010).
Barker, W. W. et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis. Assoc. Disord. 16, 203–212 (2002).
Niemantsverdriet, E. et al. Overdiagnosing vascular dementia using structural brain imaging for dementia work-up. J. Alzheimers Dis. 45, 1039–1043 (2015).
Sieben, A. et al. The genetics and neuropathology of frontotemporal lobar degeneration. Acta Neuropathol. 124, 353–372 (2012).
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De Deyn, P. Cerebrospinal fluid biomarkers in dementias. Nat Rev Neurol 11, 549–550 (2015). https://doi.org/10.1038/nrneurol.2015.175
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DOI: https://doi.org/10.1038/nrneurol.2015.175