Research into genetic susceptibilities for proteinuric glomerular diseases has uncovered key pathogenic contributions from inheritable defects in podocytes. However, much less is known about environmental factors that may initiate or propagate podocyte injury. Seminal reports in 2011 provided new mechanistic insights into how this may occur.
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Nelson, P., Alpers, C. New clues to environmental influences in glomerular disease. Nat Rev Nephrol 8, 65–66 (2012). https://doi.org/10.1038/nrneph.2011.214
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DOI: https://doi.org/10.1038/nrneph.2011.214
