Two new vasopressin antagonists, conivaptan and tolvaptan have recently been licensed for the treatment of hyponatremia in the USA. Their safety and clinical effectiveness seems promising, but high costs and the lack of data regarding their use in symptomatic patients call for further studies to clarify their future clinical role.
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R. Sterns has received honoraria as a speaker in symposia sponsored by Astellas and Otsuka. J. Hix declares no competing interests.
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Sterns, R., Hix, J. Vasopressin antagonists in hyponatremia: more data needed. Nat Rev Nephrol 7, 132–133 (2011). https://doi.org/10.1038/nrneph.2010.173
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DOI: https://doi.org/10.1038/nrneph.2010.173
