A prospective, double-blind, randomized trial has assessed whether infusion of sodium bicarbonate is protective against contrast-induced acute kidney injury (CI-AKI). Solomon et al. compared the effects of high dose sodium bicarbonate with high dose sodium chloride in patients undergoing angiography with an estimated glomerular filtration rate (eGFR) <45 ml/min/1.73 m2. No significant differences were found between the two groups in the incidence of CI-AKI, or a composite of death, dialysis, or sustained 6-month reduction in eGFR.
References
Solomon, R. et al. Randomized trial of bicarbonate or saline study for the prevention of contrast-induced nephropathy in patients with CKD. Clin. J. Am. Soc. Nephrol. 10.2215/CJN.05370514
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Bicarbonate versus saline in contrast-induced AKI. Nat Rev Nephrol 11, 566 (2015). https://doi.org/10.1038/nrneph.2015.138
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DOI: https://doi.org/10.1038/nrneph.2015.138