Among 731 patients who were referred for renal denervation at 11 European expert centres, only ∼40% were eligible for the procedure according to SYMPLICITY HTN-2 criteria and each centre's criteria. The main reasons for noneligibility were normalization of blood pressure after treatment adjustment (47%), unsuitable renal arterial anatomy (17%) and previously undetected secondary causes of hypertension (11%). These findings indicate the importance of referring patients to expert hypertension centres when considering renal denervation.