News & Comment

In mice, infusions of young cerebrospinal fluid into the brains of aged animals promote oligodendrogenesis and improve memory.

A population of spinal interneurons that express prokineticin receptor 2 is needed in mice for the rewarding, antistress and prosocial effects of pleasant touch.

Neuronal activity in a key region of the mouse hypothalamus modulates adult hippocampal neurogenesis, promoting the formation of adult-born neurons that support cognition and affective function.

In rodents, absence seizures — a prominent manifestation of generalized epilepsy — drive activity-dependent myelination in the corpus callosum, increase interhemispheric synchrony and drive increases in seizure burden over time.

In this Comment, Linzie Taylor and Karen Rommelfanger argue that white Western individualist bias is impeding progress in neuroscience and present a relational rubric of principles to mitigate this bias.

Mice show degradation of their hippocampal place code when they disengage from a virtual goal-directed navigation task.

Food craving-like behaviours in pregnant mice are associated with changes in dopamine signalling.

Two papers explore cortical contributions to the evaluation of social rank in mice.

Bright light exerts antinociceptive effects in mice by activating a visual circuit involving the periaqueductal grey.

The rapid switch from movement planning to execution is mediated by midbrain neurons that transmit information to cortex via the thalamus.

Two studies identify a mechanism linking TDP-43 pathology with genetic variants associated with increased risk of neurodegenerative disorders.

Hyperexcitability of a population of arousal-promoting neurons in the hypothalamus drives sleep instability in aged mice.

A small population of neurons coordinates spontaneous activity and regulates synapse formation in the developing fly brain.

Immune genes implicated in multiple sclerosis pathology are shown to be primed but not expressed in oligodendrocyte precursor cells in both mouse and human.

Neuropeptide Y released in the rat spleen by neurons of the suprarenal and coeliac ganglia can regulate immune-cell activation.

Androgen signalling during development may represent the mechanism underpinning some observed sex-differences in adult human brain size.