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  • Cholinergic neurons in the basal forebrain of mice influence the intake of food and body weight by regulating appetite suppression.

    • Darran Yates
    Research Highlight
    • Sian Lewis
    In Brief
  • In rats, stress promotes alcohol use by altering chloride gradients across the membranes of GABAergic neurons in the ventral tegmental area.

    • Natasha Bray
    Research Highlight
  • This study suggests that brain-derived neurotrophic factor (BDNF) is released from dendritic spines in response to activity and acts in an autocrine manner to mediate structural plasticity of the spine from which it was released.

    • Katherine Whalley
    Research Highlight
  • A loss of cholinergic inputs to the hippocampus in a mouse model of Alzheimer disease leads to memory deficits by affecting interneurons in the oriens lacunosum moleculare.

    • Natasha Bray
    Research Highlight
  • Inputs to the ventral tegmental area, which computes the reward prediction error, carry diverse signals about the actual and expected reward from distributed areas.

    • Natasha Bray
    Research Highlight
  • Early in development, GABA released from interneurons is excitatory and induces the formation of functional inhibitory and excitatory synapses in cortical layer 2/3.

    • Sian Lewis
    Research Highlight
  • Adult neurogenesis in the hippocampus is regulated by existing hippocampal connectivity and can be manipulated to enhance memory function in aged mice.

    • Katherine Whalley
    Research Highlight